2011 Fiscal Year Final Research Report
Roles of the microtubule anchor on neuronal morphogenesis
| Project/Area Number |
20500315
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Sophia University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2011
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| Keywords | 神経発生 / 分化 / 異常 |
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| Research Abstract |
Morphology of neurons is supported by microtubules. The unique arrangement of microtubules is responsible to the unique shape of neurons. In this study, we found that the centrosome, which generates microtubules has distinct molecular components and function in neurons. Neuronal centrosomes lacked ninein, which is a microbule anchor protein, and microtubule release form the centrosome was important for process elongation.
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