2010 Fiscal Year Final Research Report
L-plastin ; the possibility as a surrogate marker of polyglutamine diseases.
| Project/Area Number |
20500322
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Niigata University |
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Principal Investigator |
TOYOSHIMA Yasuko Niigata University, 脳研究所, 助教 (20334675)
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| Co-Investigator(Kenkyū-buntansha) |
ONODERA Osamu 新潟大学, 脳研究所, 准教授 (20303167)
TAKAHASHI Hitoshi 新潟大学, 脳研究所, 教授 (90206839)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ポリグルタミン病 / L-プラスチン / 治療予測マーカー / 脳神経疾患病理学 |
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| Research Abstract |
L-plastin is a protein involved in actin filament organization and endocytotic processes. We found that the expression of L-plastin increased in the brains of polyglutamine diseases. We examined the relations about the L-plastin and polyglutamine. L-plastin was shown to come to have much expression in the progress of several weeks in vitro. It is thought that L-plastin may be related with a phenomenon to need time before polyglutamine disease develops.
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