2010 Fiscal Year Final Research Report
Evaluation of peripheral nerve damage in Buruli ulcer (Mycobacterium ulcerans infection)
| Project/Area Number |
20500325
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kagoshima University |
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Principal Investigator |
GOTO Masamichi Kagoshima University, 医歯学総合研究科, 研究員 (80325779)
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| Research Collaborator |
EN Junichiro 鹿児島大学, 医歯学総合研究科, 研究員 (30587879)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ブルーリ潰瘍 / 筋・末梢神経疾患 / 抗酸菌による末梢神経障害 |
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| Research Abstract |
Deep and painless ulcers are formed in Buruli ulcer (Mycobacterium ulcerans infection). However, mechanism of painless nature was unknown. By the injection of toxic lipid mycolactone produced by M. ulcerans into murine footpads, initial hyperesthesia and subsequent hypoesthesia were observed. Histologically, Schwann cells showed swelling and necrosis. Cultured Schwann cells showed necrosis and apoptosis after the addition of mycolactone. Furthermore, nerve damage was observed in the skin biopsies of Buruli ulcer. These results indicate that nerve damage induced by mycolactone is responsible for the painless nature of this disease.
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