2010 Fiscal Year Final Research Report
The analysis of chemokines and Epstein-Barr virus in the tumor genesis of primary central nervous system lymphomas
| Project/Area Number |
20500327
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kurume University |
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Principal Investigator |
YASUO Sugita Kurume University, 医学部, 教授 (80216316)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 神経科学 / 脳神経疾患 / 病理学 |
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| Research Abstract |
In this study, Epstein-Barr virus (EBV) was implicated in the pathogenesis of primary central nervous system lymphomas (PCNLs) in immunocompetent hosts (elderly immunocompetent patients ; age≧60 years). Histologically, all cases were diagnosed as diffuse large B-cell lymphoma with extensive necrosis. EBV subtyping-PCR analysis demonstrated that many cases were EBNA 2A type and showed 30-bp LMP-1 deletion on PCR analysis. These results indicate that LMP-1 deletion may have more potent tumor-promoting activity than EBV containing the full-size LMP-1 gene in the pathogenesis of PCNLs in immunocompetent hosts. In addition, some EBV subtypes may show more potent tumor-promoting activity. Regarding chemokines, we have shown that CXCL12/CXCR4 was frequently expressed in PCNLs and other brain cells. Thus, the results suggest that the CXCL12/CXCR4 signaling mediates PCNLs development.
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Research Products
(8 results)
