2010 Fiscal Year Final Research Report
Physiological functions of nitric-oxide induced calcium-release in central nervous systems
| Project/Area Number |
20500333
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
KAKIZAWA Sho Nagasaki University, 薬学研究科, 准教授 (40291059)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 一酸化窒素 / カルシウム / 小脳 / プルキンエ細胞 / シナプス可塑性 / S-ニトロシル化 |
|---|
| Research Abstract |
The aim of this project is to examine the mechanism and functional role of nitric oxide-induce Ca2+ elevation in central neurons. In mouse cerebellar Purkinje cells, application of nitric oxide (NO) induced intracellular Ca^<2+> levels, and the elevation was revealed to be dependent on Ca^<2+> release from intracellular store. NO-induced Ca^<2+> increase was induced also by physiological patterns of neuronal activity which induces synaptic plasticity. Furthermore, the condition which blocks NO-induced Ca^<2+> increase also impaired the synaptic plasticity. There results indicate that NO-induced Ca^<2+> release is essential for the induction of synaptic plasticity in the cerebellum.
|
-
[Journal Article] TRIC-A Channels in Vascular Smooth Muscle Contribute to Blood Pressure Maintenance.2011
Author(s)
Yamazaki D., Tabara Y., Kita S., Hanada H., Komazaki S., Naitou D., Mishima A., Nishi M., Yamamura H., Yamamoto S., Kakizawa S., Miyachi H., Yamamoto S., Miyata T., Kawano Y., Kamide K., Ogihara T., Hata A., Umemura S., Soma M., Takahashi N., Imaizumi Y., Miki, T., Iwamoto T., Takeshima H.
-
Journal Title
Peer Reviewed
-
[Journal Article] Mitsugumin 23 forms amassive bowl-shaped assembly and cation-conducting channel.2011
Author(s)
Venturi E., Mio K., Nishi M., Ogura T., Moriya T., Pitt S., Okuda K., Kakizawa S., Sitsapesan R., Sato C., Takeshima H.
-
Journal Title
Biochemistry 50
Pages: 2623-2632
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Junctophilin-mediated functional crosstalk between ryanodine receptors and SK channels essential for long-term depression in the cerebellum.2008
Author(s)
Kakizawa S., Kishimoto Y., Hashimoto K., Miyazaki T., Furutani K., Shimizu H., Fukaya M., Nishi M., Sakagami H., Ikeda A., Kondo K., Kano M., Iino M., Takeshima H.
Organizer
The 8th Biennial Meeting of Asia-Pacific Society for Neurochemistry.
Place of Presentation
Shanghai, China.
Year and Date
2008-06-25
-
-
-
-
-
[Remarks] ホームページ等
-
-
