Functional Analysis of a newly Neural stem/progenitor growth factor secreted from Dendritic cells

2010 Fiscal Year Final Research Report

• Project/Area Number: 20500341
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Keio University
• Principal Investigator: OHTA Shigeki Keio University, 医学部, 講師 (20365406)
• Co-Investigator(Kenkyū-buntansha): TODA Masahiro 慶應義塾大学, 医学部, 講師 (20217508)
• Project Period (FY): 2009 – 2011
• Keywords: 神経科学移植 / 再生医療 / 神経幹細胞

Research Abstract

Macrophage migration inhibitory factor (MIF), which is secreted from dendritic cells, was identified as a new growth factor for neural stem/progenitor cells (NSPCs). MIF also could increase the self-renewal ability of NSPCs. In the present study, we identified molecules that support those functions. Furthermore, we clarified that MIF can control the cell migration of NSPCs. These findings will shed light on the therapeutic potential of MIF for the treatment of neural degenerative disorders through the endogenous NSPCs activation.

Research Products

• [Presentation] Functional analysis of macrophage migration inhibitory factor (MIF) in the mouse neural stem/progenitor cells. (2010)
  • Author(s): Ohta S, Kawakami Y, Okano H, Toda M.
  • Organizer: The 16th international conference of the international society of differentiation.
  • Place of Presentation: Nara, Japan
  • Year and Date: 20101115-20101118
• [Presentation] Functional analysis of macrophage migration inhibitory factor (MIF) in the mouse neural stem/progenitor cells. (2010)
  • Author(s): Ohta S, Kawakami Y, Okano H, Toda M.
  • Organizer: Neuro2010.
  • Place of Presentation: Kobe, Japan
  • Year and Date: 20100902-20100904
• [Presentation] MIF Acts as a direct regulation of p53 in the nuclei of glioma cells and is a novel molecular target for the treatment of glioma cancer stem cells (2009)
  • Author(s): Fukaya R, Ohta S, Kawakami Y, Matsuzaki Y, Okano H, Kawase T, Toda M.
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-20091212
• [Presentation] Macrophage migration inhibitory factor (MIF) promotes proliferation and cell survival of neural stem/progenitor cells (2009)
  • Author(s): Ohta S, Kawakami Y, Okano H, Toda M.
  • Organizer: Neuro2009
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 20090916-20090918
• [Presentation] MIF acts as a direct regulation of p53 in the nuclei of glioma cells and is a novel molecular target for the treatment of glioma cancer stem cells (2009)
  • Author(s): Fukaya R, Ohta S, Kawakami Y, Matsuzaki Y, Okano H, Kawase T, Toda M.
  • Organizer: 7th ISSCR.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20090709-20090711