2010 Fiscal Year Final Research Report
Studies on the spatiotemporal regulation of vesicle recruitment for exocytosis
| Project/Area Number |
20500342
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Sophia University |
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Principal Investigator |
KUMAKURA Konosuke Sophia University, 理工学部, 教授 (70129790)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKAWA Nobuyuki 上智大学, 理工学部, 教授 (20187107)
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| Research Collaborator |
RIVA Alessandro University of Cagliari School of medicine, Professor
HAYASHI Mitunori 上智大学, 理工学部, 特別研究員
田村 和季 上智大学, 大学院・理工学研究科, 院生
姜 裕貴 上智大学, 大学・院理工学研究科, 院生
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| Project Period (FY) |
2008 – 2010
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| Keywords | 開口分泌 / 顆粒供給 / 細胞骨格系蛋白質 / 空間的顆粒分布 / クロマフィン細胞 |
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| Research Abstract |
Present studies in chromaffin cells revealed that vesicle recruitment for exocytosis from the reserve pool to the releasable pool is a process with the intracellular translocation of the vesicles which affect the spatial localization of vesicles. Roles of Myosin V as a motor protein, and of actin filaments as rails for this recruitment were also shown.
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