Investigation of in stress-induced microglial activation

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20500359
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Nippon Medical School
• Principal Investigator: SUGAMA Syuei Nippon Medical School, 医学部, 講師 (70302461)
• Project Period (FY): 2008 – 2011
• Keywords: グリア / 神経免疫学

Research Abstract

本研究において、ストレスによって起こるミクログリア活性化メカニズム解明を進めている。主に、1.交感神経シグナルの関与、2.副腎ステロイドの作用、3.脳内サイトカインの増加のメカニズムを、動物実験モデル、培養細胞を用いて検討している。

Research Products

• [Journal Article] P2X7 receptor signaling pathway as a therapeutic target for neurodegenerative diseases. (2010)
  • Author(s): Takenouchi T, Sekiyama K, Sekigawa A, Fujita M, Waragai M, Sugama S, Iwamaru Y, Kitani H, Hashimot M.
  • Journal Title: Arch Immunol Ther Exp (Warsz). 58 Pages: 91-96
• [Journal Article] Differential microglial activation between acute stress and lipopolysaccharide treatment. (2009)
  • Author(s): Sugama S, Takenouchi T, Fujita M, Conti B, Hashimoto M.
  • Journal Title: J.Neuroimmunol 207 Pages: 24-31
• [Journal Article] Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration (2009)
  • Author(s): Sugama S, Takenouchi T, Kitani H, Fujita M, Hashimoto M.
  • Journal Title: J.Neuroimmunol. 208 Pages: 104-114
• [Journal Article] The activation of P2X7 receptor impairs lysosomal functions and stimulates the release of autophagolysosomes in microglial cells (2009)
  • Author(s): Takenouchi T, Nakai M, Iwamaru Y, Sugama S, Tsukimoto M, Fujita M, Wei J, Sekigawa A, Sato M, Kojima S, Kitani H, Hashimoto M.
  • Journal Title: J.Immunol. 182 Pages: 2051-2062
• [Journal Article] Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using Rho-dependent pathway. (2009)
  • Author(s): Takenouchi T, Iwamaru Y, Sugama S, Sato M, Hashimoto M, Kitani H
  • Journal Title: J.Immunol. 180 Pages: 7827-7839
• [Journal Article] The role of P2X7 receptor impairs lysosomal functions and stimulates the release of autophagolysosomes in microglial cells (2009)
  • Author(s): Takenouchi T, Fujita M, Sugama S, Kitani H, Hashimoto M.
  • Journal Title: Autophagy 5 Pages: 723-724
• [Journal Article] Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies (2009)
  • Author(s): Wei J, Fujita M, Nakai M, Waragai M, Sekigawa A, Sugama S, Takenouchi T, Masliah E, Hashimoto M
  • Journal Title: Am J Pathol. 174 Pages: 1891-1909
• [Journal Article] Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain. (2009)
  • Author(s): Alboni S, Cervia D, Ross B, Montanari C, Gonzalex AS, Sanchez-Alavez M, Marcondes MC, De Vries D, Sugama S, Brunello N, Blom J, Tascedda F, Conti B.
  • Journal Title: J.Neuroimmunol. 214 Pages: 43-54
• [Journal Article] Neurotoxic conversion of beta-synuclein : a novel approach to generate a transgenic mouse model of synucleinopathies? (2009)
  • Author(s): Fujita M, Sekigawa A, Sekiyama K, Sugama S, Hashimoto M.
  • Journal Title: J Neurol. 256 Pages: 286-292
• [Journal Article] Possible roles of microglial cells for neurotoxicity in clinical neurodegenerative diseases and experimental animal models (2009)
  • Author(s): Sugama S, Takenouchi T, Cho BP, Joh TH, Hashimoto M, Kitani H.
  • Journal Title: Inflamma Allergy Drug Targets 8 Pages: 277-284
• [Journal Article] Interleukin-18 in the CNS (2009)
  • Author(s): Alboni S, Cervia D, Sugama S, Conti B
  • Journal Title: J Neuroinflammation 29 Pages: 7-9
• [Journal Article] Interleukin-18 and stress. (2008)
  • Author(s): Sugama S, Conti B.
  • Journal Title: Brain res Rev. 58 Pages: 85-95
• [Journal Article] Stress-induced microglial activation may facilitate the progression of neurodegenerative disorders.
  • Author(s): Sugama S
  • Journal Title: Medical Hypotheses 73 Pages: 1031-1034
• [Journal Article] Modulation of the ATP-induced release and processing of IL-1beta in microglial cells.
  • Author(s): Takenouchi T, Sugama S, Iwamaru Y, Hashimoto M, Kitani H.
  • Journal Title: Crit Rev Immunol 29 Pages: 335-345
• [Journal Article] Ab-synuclein mtation linked to dementia produces neurodegeneration when expressed in mouse brain.
  • Author(s): Fujita M, Sugama S, Sekiyama K, Sekigawa A, et al..
  • Journal Title: Nature Communications 1 Pages: 110
• [Presentation] Cold stress induced morphological microglial activation and increased IL-1b expression in astroglial cells in rat brain. (2011)
  • Author(s): Sugama S
  • Organizer: 第88回日本生理学会大会
  • Year and Date: 20110000
• [Presentation] Astroglial response may differ from that of microglial cells in response to acute stress (2010)
  • Author(s): Sugama S
  • Organizer: 第87回日本生理学会大会
  • Year and Date: 20100000
• [Presentation] Differential microglial activation between acute stress and lipopolysaccharide treatment (2009)
  • Author(s): Sugama S
  • Organizer: 第36回国際生理学会大会(第86回日本生理学会大会)
  • Year and Date: 20090000