2010 Fiscal Year Final Research Report
Role of Phosphatidylinositol Signaling in the Activation of Volume-Regulated Anion Channels
| Project/Area Number |
20500366
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Saga University |
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Principal Investigator |
YAMAMOTO Shintaro Saga University, 医学部, 准教授 (40336110)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 受容体 / 細胞内シグナル伝達 / イオンチャネル / 膜電流 |
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| Research Abstract |
Since it is fully unknown the mechanism in the activation of Volume-regulated anion channel (VRAC) that is an important regulator of the cell-size, I studied the relationships between VRAC activation and phosphatidylinositol signaling in mouse ventricular cells. I found the attenuation of VRAC current by PIP3 depletion in type 1 diabetic mice, the inhibition of VRAC current by a 1- adrenoceptor-mediated PIP2 depletion. In addition, preliminary data suggested that the modulation of VRAC by PIP3-PDK1-Akt signaling. These results provide novel evidences in the activation of cardiac VRAC current.
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