2010 Fiscal Year Final Research Report
Functional analysis of muscle regeneration using gene-targeting and transgenic technologies
| Project/Area Number |
20500367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Kitasato University |
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Principal Investigator |
HANAOKA Kazunori Kitasato University, 理学部, 教授 (40189577)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Daisuke 北里大学, 理学部, 講師 (00260175)
KITAMOTO Takero 北里大学, 理学部, 助教 (20453516)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 筋再生 / サテライト細胞 / Lbx1 / Notch3 / マウス |
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| Research Abstract |
The results of present study demonstrate Notch3 as an important regulator for muscle repair. The data indicate Notch3 negatively regulate both proliferation and self-renewal of activated satellite cells after muscle injury. These results provide insight into the mechanisms of self-renewal and homeostatic regulation of satellite cells during muscle regeneration.
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