2010 Fiscal Year Final Research Report
Skeletal muscle specific calpain p94 mediated signal transduction system
| Project/Area Number |
20500369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | National Agricultural Research Organization |
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Principal Investigator |
OJIMA Koichi National Agricultural Research Organization, 畜産草地研究所, 研究員 (60415544)
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| Project Period (FY) |
2008 – 2010
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| Keywords | カルパイン / 骨格筋 / 筋ジストロフィー / タンパク質分解酵素 |
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| Research Abstract |
p94 is predominantly expressed in skeletal muscle and is a member of calpains that are Ca^<2+>-requiring intracellular cysteine proteases. In this study, we revealed that loss of p94 proease activity impaired adaptation to physical stress, accompanied by deficiency in exercise-dependent up-regulation of muscle ankyrin-repeat protein-2 and heat-shock proteins. Furthermore, p94 changes its localization in myocytes depending on sarcomere conditions to mediate signal transduction in response to external stress, and its protease activity maintains myocyte homeostasis, disruption of which leads to muscular dystrophy.
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