2011 Fiscal Year Final Research Report
Macaques as animal model for gamma-herpesvirus associated lymphomas
| Project/Area Number |
20500372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kyoto University |
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Principal Investigator |
SUZUKI Juri 京都大学, 霊長類研究所, 准教授 (10175408)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Takafumi 東京大学, 理学系研究科, 准教授 (20184533)
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| Project Period (FY) |
2008 – 2011
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| Keywords | ガンマヘルペスウイルス / 疾患モデル / マカク / リンパ腫 |
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| Research Abstract |
We surveyed for the prevalence of gamma-herpes virus(γHV) or sEBV and 2) found out possible malignant cases caused by theγHVs infection retrospectively in Japanese macaques(Macaca fuscata) and Taiwanese macaques(M. cyclopis). We found that the incidence of the lymphoma was very low compared to the high prevalence of sEBV in those macaque species. Two cases suffering from NK/T-cell lymphoma associated with sEBV in Japanese macaques and Taiwanese macaques were detected. Those results suggest that both two species are suitable for an animal model for human lymphoma associated withγHV.
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