2010 Fiscal Year Final Research Report
Development of the model animal for metabolic syndrome and analysis of its influence to arterial lesions.
| Project/Area Number |
20500373
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kobe University |
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Principal Investigator |
ITO Takashi Kobe University, 大学院・医学研究科, 助手 (30135793)
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| Co-Investigator(Kenkyū-buntansha) |
SHIOMI Masashi 神戸大学, 大学院・医学研究科, 准教授 (50226106)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 育種学 / モデル動物 / 循環器・高血圧 / 糖尿病 / 動物 |
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| Research Abstract |
In the present study, we have developed an animal model for metabolic syndrome by improving the WHHLMI rabbit, an animal model for spontaneous coronary atherosclerosis and myocardial infarction, and have analyzed influences of visceral fat accumulation on progression of atherosclerosis. To develop WHHLMI rabbits with metabolic syndrome, we carried out selective breeding using indices of serum levels of blood sugar and immunoreactive insulin. Metabolic syndrome of this rabbits was inherited from the parents to the offspring. Accumulation of visceral fat was increased with aging, and related to area of atherosclerotic lesions in the aorta. These results suggested that WHHLMI rabbits is a good animal model for metabolic syndrome.
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