2010 Fiscal Year Final Research Report
Development of vagal nerve stimulation therapy by computational management of hemodynamics in acute myocardial infarction
| Project/Area Number |
20500404
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
UEMURA Kazunori National Cardiovascular Center Research Institute, 循環動態制御部, 室長 (10344350)
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| Co-Investigator(Renkei-kenkyūsha) |
ZHENG Can 高知大学, 医学部・循環制御学講座, 助教 (50443495)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 急性心筋梗塞 / 迷走神経 / 心室リモデリング / 心不全 / 心筋間質蛋白分解酵素 / 心筋収縮力 / 心臓電気刺激 |
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| Research Abstract |
I investigated clinical significance of vagal nerve stimulation as an adjunct therapy to coronary reperfusion in patients with acute myocardial infarction. Using a rabbit model of myocardial ischemia reperfusion, I disclosed that early short term vagal nerve stimulation in myocardial ischemia reperfusion drastically attenuates cardiac remodeling and prevents cardiac failure in chronic phase. Using dogs, I investigated whether electrical stimulations directly applied to the heart can increase cardiac contractility thereby preventing unwanted side effects such as hypotension seen in vagal nerve stimulation. I disclosed that several methods previously reported failed to increase the contractility constantly in my experimental settings.
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