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2010 Fiscal Year Final Research Report

Fabrication of composite materials based on polarized bioceramics for vascular regeneration.

Research Project

  • PDF
Project/Area Number 20500405
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NAGAI Akiko  Tokyo Medical and Dental University, 生体材料工学研究所, 准教授 (40360599)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Kimihiro  東京医科歯科大学, 生体材料工学研究所, 教授 (70174670)
NAKAMURA Miho  東京医科歯科大学, 生体材料工学研究所, 助教 (40401385)
OU Gi  東京医科歯科大学, 生体材料工学研究所, 助教 (60451944)
TANAKA Yumi  東京医科歯科大学, 生体材料工学研究所, 助教 (00436619)
Project Period (FY) 2008 – 2010
Keywords再生医工学材料 / バイオセラミックス / 分極 / アパタイト / チタニア / 血管リモデリング
Research Abstract

We fabricated new hybrid composite materials based on polarized bioceramics. Intimal hyperplasia in injured arteries of rabbit suppressed and phenotypic conversion of smooth muscle cells stimulated in response to electrical signals which were generated by the polarized materials in this study. We expect that the new materials should be useful as vascular regenerative materials with long-lasting use and low cost.

  • Research Products

    (11 results)

All 2011 2010 2009 2008 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Comparison of enhancement of bone ingrowth into hydroxyapatite ceramics with highly and poorly interconnected pores by electrical polarization.2009

    • Author(s)
      Wang W, Ito S, Tanaka Y, Nagai A, Yamashita K.
    • Journal Title

      Acta Biomater 5

      Pages: 3132-3140

    • Peer Reviewed
  • [Journal Article] Hydroxyapatite electret accelerates reendothelialization and attenuates intimal hyperplasia occurring after endothelial removal of the rabbit carotid artery.2008

    • Author(s)
      Nagai A, Yamashita K, Imamura M, Azuma H.
    • Journal Title

      Life Sci 82

      Pages: 1162-1168

    • Peer Reviewed
  • [Journal Article] Electrical polarization and mechanism of B-type carbonated apatite ceramics.

    • Author(s)
      Nagai A, Tanaka K, Yanaka Y, Nakamura M, Hashimoto K, Yamashita K.
    • Journal Title

      J Biomed Mater Res A

      Pages: DOI33131

    • Peer Reviewed
  • [Presentation] The influence of the polarized titania coating on MG63 Cells.2010

    • Author(s)
      Nagai A, Yamashita K, et al.
    • Organizer
      3^<rd> international Congress on ceramics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      20101100
  • [Presentation] Hydroxyapatite Electret suppresses proliferation of vascular smoothmuscle cells2009

    • Author(s)
      Nagai A, Nakamura M, Yamashita K, et al.
    • Organizer
      vitro by modulation of their phenotypic conversion Society for Biomat erials
    • Place of Presentation
      San Antonio, U.S.A.
    • Year and Date
      20090400
  • [Presentation] Hydroxyapatite electret suppresses intimal hyperplasia in a rabbit model of vascular injury.2008

    • Author(s)
      Nagai A, Yamashita K, et al.
    • Organizer
      8^<th> World Biomaterial Congress
    • Place of Presentation
      The Netherlands
    • Year and Date
      20080500
  • [Book] バイオマテリアルの基礎2010

    • Author(s)
      永井亜希子, 他
    • Total Pages
      54-60
    • Publisher
      日本医学館
  • [Book] 生体材料(日本セラミックス協会編)2008

    • Author(s)
      永井亜希子, 他
    • Total Pages
      183-189
    • Publisher
      日刊工業新聞社
  • [Remarks] ホームページ等

    • URL

      http://www.tmd.ac.jp/i-mde/www/material/index2.html

  • [Patent(Industrial Property Rights)] 金属酸化物,金属材料、生体親和材料、および金属酸化物の製造方法2011

    • Inventor(s)
      山下仁大、永井亜希子、馬楚凡
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      PCT/JP2011,051672
    • Filing Date
      2011-01-27
  • [Patent(Industrial Property Rights)] セラミックスの分極処理方法及び分極処理したセラミックスを含む生体材料2009

    • Inventor(s)
      山下仁大、伊藤聡一郎、永井亜希子
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      PCT/JP2009,059433
    • Filing Date
      2009-05-22

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Published: 2012-01-26   Modified: 2016-04-21  

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