2010 Fiscal Year Final Research Report
Expression of bioactivity through nano-sized defects and its regulation
| Project/Area Number |
20500413
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Meiji University |
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Principal Investigator |
AIZAWA Mamoru Meiji University, 理工学部, 教授 (10255713)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Morio 慶應義塾大学, 医学部, 准教授 (40209656)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 水酸アパタイト / 欠陥構造 / 透過型電子顕微鏡 / 骨芽細胞 / 生体活性 |
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| Research Abstract |
Biological apatite presented in bone and teeth of mammals contains various minerals, and has lots of defects with nano-scale sizes in the crystal structure. In the present study, we fabricated hydroxyapatite ceramics including bone minerals (bone HAp ceramics) as model materials to clarify the relationship between nano-defect structure and bioactivity of biological apatite. The results of high-resolution transmission electron microscope (HR-TEM) revealed that bone HAp ceramics contained more defects and strains compared to pure HAp ceramics. In addition, osteoblasts derived from rat bone marrow cells were seeded on bone HAp ceramics, together with pure HAp ceramics as a control. The bone HAp ceramics promoted the differentiation into osteoblast compared to pure HAp ceramics. The present bone HAp ceramics may be expected as next-generation artificial bone graft.
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