2010 Fiscal Year Final Research Report
Basic Approach on Novel Synthetic Pulmonary Surfactant as Intelligent Nano-Medicine
| Project/Area Number |
20500414
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Nagasaki International University |
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Principal Investigator |
SHIBATA Wosamu Nagasaki International University, 薬学部・薬学科, 教授 (10117129)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAHARA Hiromichi 長崎国際大学, 薬学部・薬学科, 助教 (00513235)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肺サーファクタント / ナノ医薬 / 超薄膜 / 表面・界面物性 / インテリジェント・ナノ材料 / Langmuir単分子膜 / 表面電位-面積等温線 / 原子間力顕微鏡(AFM) / 蛍光顕微鏡(FM) / 偏光変調赤外反射吸収法(PM-IRRAS) |
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| Research Abstract |
Our novel lung surfactant (LS) preparations show following : An electrostatic interaction between phosphatidylglycerol and peptide prevents irreversible transformation for the peptide from α-helix to β-sheet structures. And added partially fluorinated amphiphiles may be useful potential additives for synthetic LS preparations destined for treatment of RDS in premature infants and in adults.
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Research Products
(69 results)
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[Remarks] ホームページ
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[Remarks] ホームページ
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[Remarks] ホームページ
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