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2010 Fiscal Year Final Research Report

Assessment of Cardiovascular Function in Metabolic Syndrome using Doppler Ultrasonography

Research Project

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Project/Area Number 20500421
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionKagawa University

Principal Investigator

SENDA Shoichi  Kagawa University, 医学部附属病院, 教授 (30145049)

Co-Investigator(Kenkyū-buntansha) MASUGATA Hisashi  香川大学, 医学部附属病院, 講師 (70263910)
GODA Fuminori  香川大学, 医学部附属病院, 准教授 (90294769)
Research Collaborator YAMAGAMI Ayumu  公立福生病院, 内科, 医師 (30403786)
Project Period (FY) 2008 – 2010
Keywordsメタボリックシンドローム / 心機能 / 血管機能 / 心血管危険因子 / 超音波
Research Abstract

We elucidated the cardiac structure and function of patients with metabolic syndrome by analyzing echocardiographic findings in patients with metabolic syndrome. The relative wall thickness, LV mass index, and LV ejection fraction demonstrated no difference between the two groups. However, the ratio of E to A (E/A) of transmitral flow demonstrated significant difference between the metabolic syndrome and the non-metabolic syndrome groups. Patients with metabolic syndrome demonstrated LV diastolic dysfunction even if they have neither LV hypertrophy nor systolic dysfunction. Moreover, we elucidated the LV function in patients with hypertension (HT) and diabetes (DM) in various age strata. The strain and strain rate assessed by tissue Doppler echocardiography (TDE) in the HT group and DM group showed lower values than those in the healthy control subjects in each age stratum. Furthermore, the strain and strain rate in the HT+DM group showed the lowest values among all four groups in each age stratum. Although HT or DM affected normal age-related changes in LV function, the coexistence of HT and DM had a more harmful effect on the normal age-related changes than HT alone or DM alone.

  • Research Products

    (22 results)

All 2011 2010 2009

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (4 results)

  • [Journal Article] Visit-to-visit variability in blood pressure over a 1-year period is a marker of left ventricular diastolic dysfunction in treated hypertensive patients.2011

    • Author(s)
      Masugata H, Senda S, Inukai M, Goda F, et al.
    • Journal Title

      Hypertens Res. Epub ahead of print.

    • Peer Reviewed
  • [Journal Article] Association between Echocardiographic Parameters and Brain Natriuretic Peptide Levels in Treated Hypertensive Patients.2011

    • Author(s)
      Masugata H, Senda S, Inukai M, Goda F, et al.
    • Journal Title

      Clin Exp Hypertens. 33(3)

      Pages: 187-191

    • Peer Reviewed
  • [Journal Article] Aortic Root Dilation is a Marker of Subclinical Left Ventricular Diastolic Dysfunction in Patients with Cardiovascular Risk Factors.2011

    • Author(s)
      Masugata H, Senda S, Inukai M, Himoto T, Goda F, et al.
    • Journal Title

      J Int Med Res. 39(1)

      Pages: 71-77

    • Peer Reviewed
  • [Journal Article] Differences between Hypertensive and Atherosclerotic Lesions in Retinal Arteries Assessed by Scheie's Classification in Hypertensive Patients following Stroke.2010

    • Author(s)
      Masugata H, Senda S, Inukai M, Himoto T, Goda F, et al.
    • Journal Title

      Clin Exp Hypertens. 32(6)

      Pages: 335-340

    • Peer Reviewed
  • [Journal Article] Age-related Decrease in Inferior Vena Cava Diameter Measured with Echocardiography.2010

    • Author(s)
      Masugata H, Senda S, Inukai M, Himoto T, Goda F, et al.
    • Journal Title

      Tohoku J Exp Med. 222(2)

      Pages: 141-147

    • Peer Reviewed
  • [Journal Article] Cardio-ankle vascular index for evaluating immunosuppressive therapy in a patient with aortitis syndrome.2010

    • Author(s)
      Masugata H, Senda S, Inukai M, Himoto T, Goda F, et al.
    • Journal Title

      Tohoku J Exp Med. 222(1)

      Pages: 77-81

    • Peer Reviewed
  • [Journal Article] Aortic annular velocity assessed by tissue Doppler echocardiography as a potential parameter of arterial stiffness.2010

    • Author(s)
      Masugata H, Senda S, Goda F, et al.
    • Journal Title

      Tohoku J Exp Med. 221(2)

      Pages: 169-174

    • Peer Reviewed
  • [Journal Article] Echocardiographic assessment of the cardio-renal connection : is left ventricular hypertrophy or diastolic function more closely correlated with estimated glomerular filtration rate in patients with cardiovascular risk factors?2010

    • Author(s)
      Masugata H, Senda S, Goda F, et al.
    • Journal Title

      Clin Exp Hypertens. 32(2)

      Pages: 113-120

    • Peer Reviewed
  • [Journal Article] Elevated brachial-ankle pulse wave velocity is associated with left ventricular hypertrophy in hypertensive patients after stroke.2010

    • Author(s)
      Masugata H, Senda S, Inukai M, Himoto T, Goda F, et al.
    • Journal Title

      Tohoku J Exp Med. 220(3)

      Pages: 177-182

    • Peer Reviewed
  • [Journal Article] Seasonal Blood Pressure Variation and Its Relationship to Environmental Temperature in Healthy Elderly Japanese Studied by Home Measurements.2010

    • Author(s)
      Kimura T, Senda S, Masugata H, Goda F, et al.
    • Journal Title

      Clin Exp Hypertens. 32(1)

      Pages: 8-12

    • Peer Reviewed
  • [Journal Article] Clinical significance of central blood pressure measurement in antihypertensive treatment.2010

    • Author(s)
      Masugata H, Senda S.
    • Journal Title

      Expert Rev Cardiovasc Ther. 8(6)

      Pages: 763-765

    • Peer Reviewed
  • [Journal Article] Comparison of central blood pressure and cardio-ankle vascular index for association with cardiac function in treated hypertensive patients.2009

    • Author(s)
      Masugata H, Senda S, Inukai M, Goda F, et al.
    • Journal Title

      Hypertens Res. 32(12)

      Pages: 1136-1142

    • Peer Reviewed
  • [Journal Article] Influences of Hypertension and Diabetes on Normal Age-related Changes in Left Ventricular Function as Assessed by Tissue Doppler Echocardiography.2009

    • Author(s)
      Masugata H, Senda S, Goda F, et al.
    • Journal Title

      Clin Exp Hypertens. 31(5)

      Pages: 400-414

    • Peer Reviewed
  • [Journal Article] Independent determinants of the Tei index in hypertensive patients with preserved left ventricular systolic function.2009

    • Author(s)
      Masugata H, Senda S, Goda F, et al.
    • Journal Title

      Int Heart J. 50(3)

      Pages: 331-340

    • Peer Reviewed
  • [Journal Article] Detection of increased arterial stiffness in a patient with early stage of large vessel vasculitis by measuring cardio-ankle vascular index.2009

    • Author(s)
      Masugata H, Senda S, Inukai M, Himoto T, Goda F, et al.
    • Journal Title

      Tohoku J Exp Med. 219(2)

      Pages: 101-105

    • Peer Reviewed
  • [Journal Article] Early detection of hypertension in a patient treated with sunitinib by measuring cardio-ankle vascular index.2009

    • Author(s)
      Masugata H, Senda S, Inukai M, Himoto T, Goda F, et al.
    • Journal Title

      Tohoku J Exp Med. 218(2)

      Pages: 115-119

    • Peer Reviewed
  • [Journal Article] Decline of plasma brain natriuretic peptide during enzyme replacement therapy in a female patient with heterozygous Fabry's disease.2009

    • Author(s)
      Masugata H, Senda S, Goda F, et al.
    • Journal Title

      Tohoku J Exp Med. 217(3)

      Pages: 169-174

    • Peer Reviewed
  • [Journal Article] Tissue Doppler echocardiography for predicting arterial stiffness assessed by cardio-ankle vascular index.2009

    • Author(s)
      Masugata H, Senda S, Goda F, et al.
    • Journal Title

      Tohoku J Exp Med. 217(2)

      Pages: 139-146

    • Peer Reviewed
  • [Presentation] 大動脈弁輪部速度計測の提唱:僧帽弁輪部速度との比較および大動脈硬度との関係2010

    • Author(s)
      舛形尚、千田彰一, 他
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20100917-20100919
  • [Presentation] Influences of Hypertension and Diabetes on Normal Age-related Changes in Left Ventricular Function as Assessed by Tissue Doppler Echocardiography.2010

    • Author(s)
      舛形尚, 千田彰一, et al.
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都市
    • Year and Date
      20100305-20100307
  • [Presentation] Clinical Significance of Tei Index for Predicting an Increased Risk of Cardiovascular Events in Patients with Lifestyle - Related Disease.2010

    • Author(s)
      舛形尚, 千田彰一, et al.
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都市
    • Year and Date
      20100305-20100307
  • [Presentation] One-year Alterations of the Tei Index during Antihypertensive Treatment in Elderly Hypertensive Patients : An Observational Study.2010

    • Author(s)
      舛形尚, 千田彰一, et al.
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都市
    • Year and Date
      20100305-20100307

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Published: 2012-01-26   Modified: 2016-04-21  

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