2010 Fiscal Year Final Research Report
Sonodynamic cancer therapy-the combination effects of an anticancer drug and a sonosensitizer
| Project/Area Number |
20500433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Fukuoka University |
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Principal Investigator |
SHIBAGUCHI Hirotomo Fukuoka University, 医学部, 講師 (60295061)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 超音波医科学 / 超音波力学療法 / 超音波感受性物質 / がん / 非侵襲的治療 |
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| Research Abstract |
Low-intensity ultrasound irradiation with a sonosensitizer (sonodynamic therapy, SDT) is one of the promising candidates for cancer therapy because of the deeper tissue penetrating ability than light and lower phototoxicity than photodynamic therapy with a photosensitizer. In order to develop SDT, DEG, a novel sonosensitizer, was characterized and assessed. Furthermore, Combinational effect of an anticancer drug and DEG on SDT was evaluated both in vitro and in vivo. The synergistic antitumor effect was observed in mouse xenograft model as well as in vitro cytotoxic assay in combination of DEG and anticancer drug on ultrasound irradiation, suggesting that the SDT in combination of DEG and anticancer drug might be a useful treatment for cancer.
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[Journal Article] PPARalpha ligand WY14643 reduced acute rejection after rat lung transplantation with the upregulation of IL-4, IL-10 and TGFbeta mRNA expression.2009
Author(s)
Yanagisawa J, Shiraishi T, Iwasaki A, Maekawa S, Higuchi T, Hiratuka M, Tanaka T, Shibaguchi H, Kuroki M, Shirakusa T.
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Journal Title
J Heart Lung Transplant 28(11)
Pages: 1172-1179
Peer Reviewed
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[Journal Article] Claudin-1 protein is a major factor involved in the tumorigenesis of colorectal cancer.2009
Author(s)
Huo Q, Kinugasa T, Wang L, Huang J, Zhao J, Shibaguchi H, Kuroki M, Tanaka T, Yamashita Y, Nabeshima K, Iwasaki H, Kuroki M.
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Journal Title
Anticancer Res 29(3)
Pages: 851-857
Peer Reviewed
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[Journal Article] Association between the expression of chemokine receptors CCR7 and CXCR3, and lymph node metastatic potential in lung adenocarcinoma.2008
Author(s)
Maekawa S, Iwasaki A, Shirakusa T, Kawakami T, Yanagisawa J, Tanaka Shibaguchi H, Kinugasa T, Kuroki M, Kuroki M.
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Journal Title
Oncol Rep, 19(6)
Pages: 1461-1468
Peer Reviewed
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