2010 Fiscal Year Final Research Report
A New Therapeutic Approach for Dysphagia : Modification of Deglutition Center in Cerebrum and Pons
| Project/Area Number |
20500440
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YAMAWAKI Masanaga Tokyo Medical and Dental University, 医学研究科, 教授 (30302855)
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| Co-Investigator(Kenkyū-buntansha) |
DAN Ippeita 自治医科大学, 医学部, 准教授 (20399380)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 嚥下運動 / 脳機能 / CPG / 嚥下障害 / NIRS |
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| Research Abstract |
There are subcortical and cortical centers above the brainstem that induce swallowing movement, however, their specific role and connections are not well understood.We applied functional near-infrared spectroscopy (fNIRS) for brain mapping in swallowing and swallow-related movements Twenty-five of volunteers were examined by fNIRS. Subjects sitting on the chair were put 34-channel holder of OMM-2000 (Shimadzu, Kyoto, Japan). Sensorimotor cortex and frontal lobe were set as the region of the interest. We performed, 1) blocked motor tasks (hand grip, tongue protrusion), 2) event-related tasks (command or non-command swallow). The statistical method used was a general linear model employing a two-level summary statistics approach for random effects analysis with a one-tailed t test. Activation areas in each blocked task were detected separately in SMI (p < o.o5 by Student t, one-tailed, FDR controlled). During bolus swallowing, activation was detected in tongue SMI and BA 6 (p < o.o5, one-tailed, FDR controlled). The haemodynamic pattern observed during swallowing was different during the command versus non-command tasks in BA 6 and BA 40 (p < o.o5, two-tailed, not corrected). In accordance with prior reports, BA 4, BA 3,1,2, BA 6 were activated both in command and non-command swallow in our study. The haemodynamic pattern during swallowing appeared different in command versus non-command tasks in BA 6 and BA 40. Our findings suggest that the sensory input is more important in non-commandthan in command swallow. These data show that cortical process to initiate swallowingmovements is altered by the triggers.
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[Journal Article] Mapping of optical pathlength of human adult head at multi-wavelengths in near infrared spectroscopy.2010
Author(s)
Katagiri A, Dan I, Tuzuki D, Okamoto M, Yokose N, Igarashi K, Hoshino T, Fujiwara T, Katayama Y, Yamaguchi Y, Sakatani K.
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Journal Title
Advances in Experimental Medicine & Biology 662
Pages: 205-212
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