2010 Fiscal Year Final Research Report
Effects of voluntary exercise on expression of neurotrophic factors and neurotransmitter levels in rat brain
| Project/Area Number |
20500453
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kagoshima University |
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Principal Investigator |
OHWATASHI Akihiko Kagoshima University, 医学部, 助教 (30295282)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Satoshi 鹿児島大学, 医学部歯学部附属病院, 講師 (00343369)
YOSHIDA Akira 鹿児島大学, 医歯学総合研究科, 助教 (40347109)
KAWAHIRA Kazumi 鹿児島大学, 医歯学総合研究科, 教授 (20117493)
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| Project Period (FY) |
2008 – 2010
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| Keywords | マイクロダイアリシス / 神経伝達物質 / 脳の可塑性 / 運動療法 / 機能回復 |
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| Research Abstract |
Extracellular concentrations of monoamines were investigated in the striatum and hippocampus before, during, and after treadmill exercise using microdialysis technique. It was found that serotonin and norepinephrine levels were increased during treadmill running and then returned to baseline levels ; however, dopamine levels peaked after treadmill exercise. Serotonin levels were increased in the hippocampus during treadmill running after 1 week of treadmill exercise.
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