2010 Fiscal Year Final Research Report
Study of interaction between genetic and environmental factors for high-altitude pulmonary edema.
| Project/Area Number |
20500559
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
KASHIMURA Osamu Tokyo University of Agriculture, 国際食料情報学部, 教授 (40161020)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Tomonobu 東京農業大学, 生物産業学部, 准教授 (30235220)
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| Project Period (FY) |
2008 – 2010
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| Keywords | スポーツ環境学 / 肺血管 |
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| Research Abstract |
We used F344 which high-altitude pulmonary edema was hard to develop and WKY which it was easy compared eNOS, ACE receptor and HIF1α protein expressions, in the pulmonary and systemic arteries by chronic and acute exposures to hypoxia, and inspected association with the high-altitude pulmonary edema onset. Thecoefficients of pulmonary vascular filtration were significantly shown lower in F344 group in comparison with WKY group. With the F344 rats, hypoxic pulmonary vasoconstriction was inhibited after the chronic exposure to hypoxia, and right ventricular hypertrophy and pulmonary hyperplasia were small, and the endothelial nitric oxide synthase activities and protein expressions in pulmonary arteries were high. The onsets of the high-altitude pulmonary edema depended on pulmonary vascular sensitivities to hypoxia, and the contribution of genetic factors became clear.
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