2010 Fiscal Year Final Research Report
Effects of prolyl hydroxylase inhibitor treatment on oxygen sensing mechanism in skeletal muscles
| Project/Area Number |
20500571
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Hokkaido University of Education |
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Principal Investigator |
SUZUKI Junichi Hokkaido University of Education, 教育学部, 准教授 (80261379)
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| Project Period (FY) |
2008 – 2010
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| Keywords | スポーツ生理学 / 運動生理学 / 酸素センシング機構 |
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| Research Abstract |
Recently a family of O2-dependent prolyl hydroxylase domain-containing enzymes has been identified as a cellular oxygen sensing mechanism. Reduced prolyl hydroxylase activity facilitates an accumulation of hypoxia-inducible factor (HIF-1alpha). This study was designed to examine the effects of prolyl hydroxylase inhibitor, supplementation on muscle oxygen sensing mechanism. The present results suggest that prolyl hydroxylase inhibitor facilitates capillary angiogenesis and glycolytic enzyme activity via HIF-1alpha upregulation in hind-leg muscles.
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