2010 Fiscal Year Final Research Report
Mobilization of endothelial progenitor cells and vascular dendritic cells of bone marrow origin in the organs and vascular system of the whole body
| Project/Area Number |
20500573
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Akita University |
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Principal Investigator |
NANJO Hiroshi Akita University, 医学部, 准教授 (70250892)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Mikio 秋田大学, 大学院・医学系研究科, 技術長 (20375306)
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| Co-Investigator(Renkei-kenkyūsha) |
MASUDA Hirotake 秋田大学, 大学院・医学系研究科, 教授 (60103462)
KAWAMURA Koichi 秋田大学, 大学院・医学系研究科, 准教授 (00091801)
TAKAHASHI Masato 秋田大学, 大学院・医学系研究科, 助教 (10315806)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 内皮幹細胞 / 樹状突起細胞 / 血管樹状細胞 / 骨髄由来 / 活性化 |
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| Research Abstract |
Appearance and distribution of endothelial progenitor cells and vascular dendritic cells of bone marrow origin were examined in the organs and vascular system in the whole body using bone marrow transplantation chimeric mice. The main results were as follows. A lot of endothelial cells of bone marrow origin were seen in the cardiac capillaries. No endothelial cell of bone marrow origin was seen in the aorta except for the orifice of the ascending aorta and aortic valve. Many vascular dendritic cells of bone marrow origin were mobilized in the non-atherosclerotic aorta in all the mice. In proportion as the mice were older, vascular dendritic cells of bone marrow origin increased and their clusters were seen in almost all the aorta from the aortic orifice to the abdominal aorta. Vascular dendritic cells of bone marrow origin may be some defensive role for atherosclerosis.
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