2010 Fiscal Year Final Research Report
Does habitual voluntary exercise attenuate sarcopenic symptom?
| Project/Area Number |
20500575
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Toyohashi University of Technology |
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Principal Investigator |
SAKUMA Kunihiro Toyohashi University of Technology, 総合教育院, 准教授 (60291176)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 加齢 / 骨格筋 / 運動 / 筋肥大 / サルコペニア / SRF |
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| Research Abstract |
Using senescent mice (24-month-old), I investigated the adaptive changes in SRF-linked molecule in skeletal muscle. In aged mice, we observed the mardked reductions in the amount of SRF (in cytosol fraction) and MRTF-A (nuclear fraction) proteins in quadriceps muscle. The expression levels of STARS, a possible SRF-upstream mediator, were also decreased in the muscle. Although voluntary exercise attenuated the sarcopenic symptom, there is no significant change in SRF-linked molecules.
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