2010 Fiscal Year Final Research Report
Biochemical Mechanism of Coenzyme Q Redox Cycle for Showing Decreased Fatigue During Aerobic Exercise
| Project/Area Number |
20500587
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
OKAMOTO Tadashi Kobe Gakuin University, 薬学部, 教授 (80194398)
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| Co-Investigator(Kenkyū-buntansha) |
OKUNO Masaaki 神戸学院大学, 薬学部, 助教 (40359790)
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| Project Period (FY) |
2008 – 2010
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| Keywords | コエンザイムQ / ユビキノン / 有酸素運動 / 酸素ラジカル / 疲労 |
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| Research Abstract |
The dynamics of CoQ10 antioxidant activities in vivo have not yet been fully elucidated, especially regarding the elimination of excessive oxygen radicals produced during intense aerobic exercise. The present study investigated the protective effects of CoQ10 against oxidative stress induced by aerobic swimming exercise.
Protective effects of CoQ10 were observed in 4-week CoQ10 administration such as decreasing in serum lactate level and serum LDH activities, elongation swimming duration. Moreover, NADPH-CoQ reductase activity also increased in CoQ10 administration group. These results suggest that the reduced form of CoQ10 with NADPH-CoQ reductase constituted a fundamental defense system against oxidative stress and fatigue induced by aerobic exercise.
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