2010 Fiscal Year Final Research Report

Biochemical Mechanism of Coenzyme Q Redox Cycle for Showing Decreased Fatigue During Aerobic Exercise

Research Project

Project/Area Number	20500587
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Sports science
Research Institution	Kobe Gakuin University
Principal Investigator	OKAMOTO Tadashi Kobe Gakuin University, 薬学部, 教授 (80194398)
Co-Investigator(Kenkyū-buntansha)	OKUNO Masaaki 神戸学院大学, 薬学部, 助教 (40359790)
Project Period (FY)	2008 – 2010
Keywords	コエンザイムQ / ユビキノン / 有酸素運動 / 酸素ラジカル / 疲労
Research Abstract	The dynamics of CoQ10 antioxidant activities in vivo have not yet been fully elucidated, especially regarding the elimination of excessive oxygen radicals produced during intense aerobic exercise. The present study investigated the protective effects of CoQ10 against oxidative stress induced by aerobic swimming exercise. Protective effects of CoQ10 were observed in 4-week CoQ10 administration such as decreasing in serum lactate level and serum LDH activities, elongation swimming duration. Moreover, NADPH-CoQ reductase activity also increased in CoQ10 administration group. These results suggest that the reduced form of CoQ10 with NADPH-CoQ reductase constituted a fundamental defense system against oxidative stress and fatigue induced by aerobic exercise.

(2 results)