• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

The effects of exercise-induced stress on the brains of spontaneously hypertensive rats

Research Project

  • PDF
Project/Area Number 20500588
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionKawasaki Medical School

Principal Investigator

MIYAMOTO Osamu  Kawasaki Medical School, 医学部, 教授 (00253287)

Co-Investigator(Kenkyū-buntansha) SUMITANI Kazunori  香川大学, 医学部, 教務職員 (40294772)
Project Period (FY) 2008 – 2010
Keywordsダークニューロン / 海馬 / 高血圧発症モデルラット / 運動ストレス / 酸化障害 / エイコサペンタエン酸
Research Abstract

The effects of hard exercise on the brains were investigated using spontaneously hypertensive rats (SHR). The dark neurons appeared in the hippocampus in SHR after 3-wk exercise, but not in normotensive rats. Protein carbonylation were observed in the SHR brains and the appearance of dark neurons was inhibited by administration of eicosapentaenoic acid. These results suggest that the exercise-induced oxidative stress damages brain and SHR is vulnerable to oxidative stress.

  • Research Products

    (11 results)

All 2011 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (7 results)

  • [Journal Article] Anti-oxidative effects of D-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat2011

    • Author(s)
      Nakamura T, Tanaka S, Hirooka K, Toyoshima T, Kawai N, Tamiya T, Shiraga F, Tokuda M, Keep R, Itano T, Miyamoto O
    • Journal Title

      Neurosci lett Vol.487

      Pages: 103-106

    • Peer Reviewed
  • [Journal Article] Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model2009

    • Author(s)
      Tanaka S, Nakamura T, Sumitani K, Takahashi F, Konishi R, Itano T, Miyamoto O
    • Journal Title

      Neurosci Res Vol.65

      Pages: 79-87

    • Peer Reviewed
  • [Journal Article] 運動による脳虚血耐性獲得とその機序の解明2009

    • Author(s)
      宮本修
    • Journal Title

      両備てい園記念財団試験研究論叢 Vol.24

      Pages: 115-121

  • [Journal Article] 3CB2, a marker of radial glia, expression after experimental intracerebral hemorrhage : role of thrombin2008

    • Author(s)
      Nakamura T, Miyamoto O, Toyoshima T, Hirooka K, Kawai N, Shiraga F, Tamiya T, Xi G, Keep R, Itano T
    • Journal Title

      Brain Res Vol.1226

      Pages: 156-162

    • Peer Reviewed
  • [Presentation] 脳梗塞後の短期間運動が認知機能の回復に及ぼす効果2010

    • Author(s)
      氷見直之,高橋尚,古我知成,丸山恵美,国安勝司,宮本修
    • Organizer
      第65回日本体力医学会
    • Place of Presentation
      市川市
    • Year and Date
      2010-09-16
  • [Presentation] キンドリングマウスにおけるNG2細胞の形態的変化について2010

    • Author(s)
      板野俊文,中川利孝,田中眞司,中村丈洋,豊島哲彦,宮本修
    • Organizer
      第87回日本生理学会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-05-20
  • [Presentation] マイクロスフェア注入による脳梗塞ラットに対する運動の初期効果2010

    • Author(s)
      氷見直之、高橋尚、中村恵美、国安勝司、成田和彦、古我知成、宮本修
    • Organizer
      第87回日本生理学会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-05-19
  • [Presentation] マイクロスフェア注入による脳梗塞がトレッドミル走行時の乳酸性閾値に及ぼす影響2010

    • Author(s)
      高橋尚、氷見直之、国安勝司、宮本修、古我知成
    • Organizer
      第87回日本生理学会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-05-19
  • [Presentation] Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model2009

    • Author(s)
      Miyamoto O, Tanaka S, Nakamura T, Konishi R, Itano T
    • Organizer
      International Congress of Physiological Sciences
    • Place of Presentation
      kyoto
    • Year and Date
      2009-08-01
  • [Presentation] Delayed protease inhibitor treatment reduces brain damage after intracerebral hemorrhage in rat2009

    • Author(s)
      Nakamura T, Okabe N, Lu F, Kuroda Y, Tamiya T, Miyamoto O, Itano T
    • Organizer
      International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-08-01
  • [Presentation] ラット脳出血モデルにおける運動によるプレコンディショニングの効果2008

    • Author(s)
      住谷和則、中村丈洋、山神眞一、宮本賢作、宮本修
    • Organizer
      第63回日本体力医学会
    • Place of Presentation
      別府市
    • Year and Date
      2008-09-18

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi