2010 Fiscal Year Final Research Report

The influence and action of antioxidant vitamin supplementation on thermoregulatory vasomotion in human skin

Research Project

Project/Area Number	20500589
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Sports science
Research Institution	University of Occupational and Environmental Health, Japan
Principal Investigator	YAMAZAKI Fumio University of Occupational and Environmental Health, Japan, 産業保健学部, 講師 (80269050)
Co-Investigator(Renkei-kenkyūsha)	TAKAHARA Kazuo 産業医科大学, 産業保健学部, 教授 (30163306) SEKI Meikan 産業医科大学, 産業保健学部, 教授 (40163092)
Project Period (FY)	2008 – 2010
Keywords	アスコルビン酸 / 皮膚血流量 / 暑熱負荷 / 寒冷負荷 / 活性酸素
Research Abstract	To elucidate the influence and action mechanism of antioxidant vitamin supplementation on thermoregulatory vasomotor function in human skin, we administered vasoactive agents with and without vitamin C in forearm skin and examined the vasomotor responses at the treated skin sites during thermal stress. The present study suggests that antioxidant vitamin supplementation increases the vasodilator response during whole-body heating but does not alter the vasoconstrictor response during whole-body cooling, while it inhibits the vasoconstrictor response to local skin cooling through adrenoceptor-dependent mechanism.