2010 Fiscal Year Final Research Report
Assessment of psychological stress by analyzing CD4 positive T cell subsets
| Project/Area Number |
20500592
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Gunma University |
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Principal Investigator |
OGAWARA Hatsue Gunma University, 医学部, 教授 (60134293)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Hirokazu 群馬大学, 医学部, 教授 (40166260)
HANDA Hiroshi 群馬大学, 大学院・医学系研究科, 講師 (90282409)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ストレス / POMS / 心理テスト / 唾液アミラーゼ活性 / 唾液クロモグラニンA / CD4陽性T細胞 / CD4 / CD8比 / Th1 / Th2比 / 制御性T細胞 |
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| Research Abstract |
To assess the psychological stress of students before taking a national-license examination, we investigated the changes of CD4-positive T-cell subsets in peripheral blood, salivary amylase activity and salivary chromogranin A (sCgA) concentration in addition to conducting Profile of Mood States (POMS) psychological tests. sCgA concentration was significantly correlated with the POMS T-A scale, and higher percentages of CD4+CD25+ T cells and greater Th1/Th2 ratios were observed with increasing sCgA concentrations. These results suggest that psychological stress affects the T-cell subsets related to acquired immunity.
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