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2010 Fiscal Year Final Research Report

Anti-atherogenic effects of water exercise : Analysis of the mechanism using 3D tissue-engineered vessel

Research Project

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Project/Area Number 20500629
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionJuntendo University

Principal Investigator

SHIMADA Kazunori  Juntendo University, 医学部, 准教授 (60327814)

Co-Investigator(Kenkyū-buntansha) SUZUKI Daichi  順天堂大学, 健康スポーツ科学部, 准教授 (80255653)
Project Period (FY) 2008 – 2010
Keywords生活習慣病 / 水中運動 / 動脈硬化 / 免疫応答
Research Abstract

Expression of activation markers of dendritic cells (DCs), such as CCL19 and CCR7, were significantly higher in patients with acute coronary syndrome (ACS) than in patients without ACS. Voluntary exercise ameliorated the initiation and progression of atherosclerosis via inhibition of the accumulation of immune cells, such as DCs, macrophages, lymphocytes. In 3D tissue-engineered vessels, wall-embedded DCs responded to lipopolysaccharide, resulting in stimulating autologous CD4 T cells. The levels of CRP and CCL19 were lower in subjects with exercise habits, including water exercise, than those without exercise habits. Therefore, regular exercise, including water exercise, may have anti-inflammatory and immmunomodulating effects.

  • Research Products

    (35 results)

All 2011 2010 2009 2008

All Journal Article (11 results) Presentation (15 results) Book (9 results)

  • [Journal Article] Involvement of Cholesterol-enriched Microdomains in Class A Scavenger Receptor-mediated Responses in Human Macrophages.2011

    • Author(s)
      Kiyanagi T, Iwabuchi K, Shimada K, et al.
    • Journal Title

      Atherosclerosis. 215

      Pages: 60-69

  • [Journal Article] Different responses to oxidized low-density lipoproteins in human polarized macrophages.2011

    • Author(s)
      Hirose K, Iwabuchi K, Shimada K, et al.
    • Journal Title

      Lipids Health Dis. 10

      Pages: 1

  • [Journal Article] Voluntary Exercise Ameliorates the Progression of Atherosclerotic Lesion Formation via Anti-inflammatory Effects in Apolipoprotein E-Deficient Mice.2010

    • Author(s)
      Fukao K, Shimada K, et al.
    • Journal Title

      J Atheroscler Tromb. 17

      Pages: 1226-1236

  • [Journal Article] Effects of phase III cardiac rehabilitation on mortality and cardiovascular events in elderly patients with stable coronary artery disease.2010

    • Author(s)
      Onishi T, Shimada K, et al.
    • Journal Title

      Circ J. 74

      Pages: 709-714

  • [Journal Article] Short-term 20-mg atorvastatin therapy reduces key inflammatory factors including c-Jun N-terminal kinase and dendritic cells and matrix metalloproteinase expression in human abdominal aortic aneurysmal wall.2009

    • Author(s)
      Kajimoto K, Miyauchi K, Kasai T, Shimada K, et al.
    • Journal Title

      Atherosclerosis. 206

      Pages: 505-11

  • [Journal Article] Relationship between exercise tolerance and muscle strength following cardiac rehabilitation : Comparison of patients after cardiac surgery and patients with myocardial infarction.2009

    • Author(s)
      Sumide T, Shimada K, et al.
    • Journal Title

      J.Cardiol. 54

      Pages: 273-281

  • [Journal Article] Immune System and Atherosclerotic Disease : Heterogeneity of leukocyte subsets participating in the pathogenesis of atherosclerosis.2009

    • Author(s)
      Shimada K
    • Journal Title

      Circ J. 73

      Pages: 994-1001

  • [Journal Article] Effects of a cardiac rehabilitation in patients with metabolic syndrome after coronary artery bypass grafting.2009

    • Author(s)
      Onishi T, Shimada K, et al.
    • Journal Title

      J.Cardiol. 53

      Pages: 381-387

  • [Journal Article] Enhanced Production of Nitric Oxide, Reactive Oxygen Species, and Pro-Inflammatory Cytokines in Very Long Chain Saturated Fatty Acid-Accumulated Macrophages.2008

    • Author(s)
      Yanagisawa N, Shimada K, et al.
    • Journal Title

      Lipids Health Dis. 7

      Pages: 48

  • [Journal Article] Effects of a phase III cardiac rehabilitation program on physical status and lipid profiles in elderly patients with coronary artery disease : Juntendo cardiac rehabilitation program (J-CARP).2008

    • Author(s)
      Seki E, Watanabe Y, Shimada K, et al.
    • Journal Title

      Circ J. 72

      Pages: 1230-1234

  • [Journal Article] Vessel Wall-Embedded Dendritic Cells Induce T-Cell Autoreactivity and Initiate Vascular Inflammation.2008

    • Author(s)
      Han JW, Shimada K, et al.
    • Journal Title

      Circ Res. 102

      Pages: 546-553

  • [Presentation] Transcriptional Analysis of Human Polarized Macrophages in Oxidized Low-density Lipoprotein Uptake.2011

    • Author(s)
      Hirose K, Shimada K, et al.
    • Organizer
      75th Annual Meeting of JCS.
    • Place of Presentation
      (postponed) Yokohama
    • Year and Date
      2011-03-20
  • [Presentation] Circulating Oxidized LDL Level and LDL-cholesterol/HDL-cholesterol Ratio in the Assessment of Future Cardiac Events in Patients with Coronary Artery Disease.2011

    • Author(s)
      Sai E, Shimada K, et al.
    • Organizer
      75th Annual Meeting of JCS.
    • Place of Presentation
      (postponed) Yokohama
    • Year and Date
      2011-03-20
  • [Presentation] Impact of Diabetes on Muscle Mass, Muscle Strength, and Exercise Tolerance in Patients after Coronary Artery Bypass Grafting.2011

    • Author(s)
      Nishitani M, Shimada K, et al.
    • Organizer
      75th Annual Meeting of JCS.
    • Place of Presentation
      (postponed) Yokohama
    • Year and Date
      2011-03-19
  • [Presentation] Cholesterol-enriched Microdomains on Class A Scavenger Receptor-mediated Modified LDL Uptake in Human Macrophages.2011

    • Author(s)
      Kiyanagi T, Shimada K, et al.
    • Organizer
      75th Annual Meeting of JCS.
    • Place of Presentation
      (postponed) Yokohama
    • Year and Date
      2011-03-19
  • [Presentation] 自発的運動は動脈硬化の発症および進展を抑制する2010

    • Author(s)
      深尾宏祐,島田和典,ほか
    • Organizer
      日本心臓病学会
    • Place of Presentation
      東京
    • Year and Date
      20100900
  • [Presentation] 水中運動と健康関連指標に関する疫学研究2010

    • Author(s)
      稲葉裕,鈴木大地,島田和典,ほか
    • Organizer
      順天堂医学
    • Place of Presentation
      東京
    • Year and Date
      20100800
  • [Presentation] 運動とメタボリックシンドローム2010

    • Author(s)
      河盛隆造,田村好史,代田浩之,島田和典,ほか
    • Organizer
      順天堂医学
    • Place of Presentation
      東京
    • Year and Date
      20100800
  • [Presentation] 心血管疾患に対する運動トレーニングを含めた包括的介入の効果2010

    • Author(s)
      代田浩之,島田和典,ほか
    • Organizer
      順天堂医学
    • Place of Presentation
      東京
    • Year and Date
      20100800
  • [Presentation] Powerful Impact of Combination Therapy of Voluntary Exercise with Valsartan orFluvastatin on Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice.2010

    • Author(s)
      Fukao K, 島田和典, et al.
    • Organizer
      74th Annual Meeting of JCS.
    • Place of Presentation
      Kyoto Int. Conf. Center.
    • Year and Date
      2010-03-07
  • [Presentation] Effect of Voluntary Exercise for Prevention of Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice.2010

    • Author(s)
      Fukao K, Shimada K, et al.
    • Organizer
      74th Annual Meeting of JCS.
    • Place of Presentation
      Kyoto Int. Conf. Center.
    • Year and Date
      2010-03-05
  • [Presentation] Voluntary Exercise for the Prevention of Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice.2009

    • Author(s)
      島田和典
    • Organizer
      Expert Meeting of Hypertension and Metabolic Syndrome.
    • Place of Presentation
      Takanawa, Tokyo
    • Year and Date
      2009-11-27
  • [Presentation] Combination Therapy of Voluntary Exercise with Valsartan or Fluvastatin for Prevention of Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice.2009

    • Author(s)
      Fukao K, Shimada K, et al.
    • Organizer
      American Heart Association Scientific Session 2009.
    • Place of Presentation
      Orlando, FL
    • Year and Date
      2009-11-18
  • [Presentation] Clinical Evidence of Activation of Monocyte-derived Dendritic Cells in Patients with Acute Coronary Syndrome.2009

    • Author(s)
      Sumiyoshi K, Shimada K, et al.
    • Organizer
      73th Annual Meeting of JCS.
    • Place of Presentation
      Ohsaka
    • Year and Date
      2009-03-20
  • [Presentation] Impact of phase III cardiac rehabilitation program on mortality in elderly patients with stable coronary artery disease.2008

    • Author(s)
      Onishi T, Shimada K, Sumide T, Ohmura H, Kume A, Masaki Y, Fukao K, Sato H, Sunayama S, Naito H, Amano A, Daida H
    • Organizer
      13^<th> Annual congress of the Europian College of Sport Science
    • Place of Presentation
      Portrugal
    • Year and Date
      20080709-20080712
  • [Presentation] Deletion of Fc Receptor Ameliorates Progression of Atherosclerotic Lesions in LDL Receptor Knockout Mice : Protective Role against Vascular Inflammation and Oxidative Stress.2008

    • Author(s)
      Sumiyoshi K, Shimada K, et al.
    • Organizer
      American Heart Association, Scientific Session.
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2008-11-11
  • [Book] 呼吸と循環(心臓リハビリテーション・運動療法のプラーク安定化作用と血管保護効果 59巻)2011

    • Author(s)
      西谷美帆,島田和典,ほか
    • Total Pages
      227-232
  • [Book] 心臓リハビリテーション(動脈硬化と心臓リハビリテーション 16)2011

    • Author(s)
      島田和典、ほか
    • Total Pages
      40-43
  • [Book] 日本臨床栄養学会雑誌(心大血管リハビリテーションにおける栄養指導 32)2011

    • Author(s)
      島田和典,ほか
    • Total Pages
      126-132
  • [Book] 循環plus(冠動脈硬化の一次予防 11)2010

    • Author(s)
      蔡榮龍,島田和典
    • Total Pages
      10-12
  • [Book] 保健の科学(心血管系への対策 51)2009

    • Author(s)
      大坂裕通,島田和典
    • Total Pages
      593-598
  • [Book] 臨床栄養療法スタッフマニュアル(編集 清野裕ほか)(虚血性心疾患)2009

    • Author(s)
      松森理枝,島田和典,ほか
    • Total Pages
      420-425
    • Publisher
      医学書院,東京
  • [Book] 分子糖尿病学の進歩(監修 矢崎義雄 血糖コントロールにより大血管症は抑えられるかどうか)2009

    • Author(s)
      松森理枝,島田和典,ほか
    • Total Pages
      106-113
    • Publisher
      金原出版,東京
  • [Book] 綜合臨床(虚血性心疾患診療の新時代 リスクファクター 57巻)2008

    • Author(s)
      西谷美帆,島田和典,ほか
    • Total Pages
      227-232
  • [Book] Current Therapy.(心血管病の治療最前線 26巻)2008

    • Author(s)
      松森理枝,島田和典,ほか
    • Total Pages
      55-59

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Published: 2012-01-26   Modified: 2016-04-21  

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