2010 Fiscal Year Final Research Report
Amelioration of tumor susceptibility by lifestyle modification in Snark-knockout mice
| Project/Area Number |
20500643
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
TSUCHIHARA Katsuya National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 臨床開発センター, 室長 (00415514)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生活習慣病 / 癌 |
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| Research Abstract |
SNARK (SNF1/AMPK-related kinase)-deficient mice exhibit metabolic disorders. IL-6, which has been reported to regulate whole body energy expenditure, was low in these mice. Voluntary exercise restored serum IL-6 level and ameliorated metabolic disorders. Snark-deficient mice also exhibited increased carcinogen-induced colorectal tumorigenesity. Both administration of recombinant IL-6 and voluntary exercise significantly reduced the tumor susceptibility. These findings imply that the restoration of systemic IL-6 level suppressed the tumorigenesity of Snark-deficient mice and the concomitance of tumorigenesis and systemic metabolic disorders were suggested.
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[Journal Article] Goodyear LJ. Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.2010
Author(s)
Koh HJ, Toyoda T, Fujii N, Jung MM, Rathod A, Middelbeek RJ, Lessard SJ, Treebak JT, Tsuchihara K, Esumi H, Richter EA, Wojtaszewski JF, Hirshman MF
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Journal Title
Proc Natl Acad Sci USA 107(35)
Pages: 15541-15546
Peer Reviewed
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[Remarks] ホームページ等
