2010 Fiscal Year Final Research Report

Role of dietary protein on the regulation of brain protein synthesis in aged rats

Research Project

Project/Area Number	20500706
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Eating habits, studies on eating habits
Research Institution	Aichi University of Education
Principal Investigator	HAYASE Kazutoshi Aichi University of Education, 教育学部, 教授 (10144180)
Co-Investigator(Renkei-kenkyūsha)	TUJIOKA Kazuyo 桜花学園大学, 保育学部, 准教授 (90440809) YOKOGOSHI Hidehiko 静岡県立大学, 食品栄養科学部, 教授 (70109320)
Project Period (FY)	2008 – 2010
Keywords	脳タンパク質合成 / タンパク質栄養 / 開始因子 / 成長ホルモン / アミノ酸
Research Abstract	The purpose of present study was to determine the mechanism by which the quality and quantity affect the brain protein synthesis in aged rats. The plasma concentration of growth hormone (GH), the concentration of leucine in the brain, and the phosphorylation of S6K1 and 4E-BP1 in the brains decrined with a decrease of quality and quantity of dietary protein. The protein synthesis rates in the brains of hypophysectomized rats with GH were significantly greater than those in hypophysectomized rats without GH. The results suggest that the GH treatment and the phosphorylation of eukaryotic initiation factors are at least partly related to the brain protein synthesis.

(3 results)