2010 Fiscal Year Final Research Report
Expression and activation of NAD(P)H oxidase in adult offspring programmed by maternal protein restriction
| Project/Area Number |
20500710
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Aomori University of Health and Welfare |
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Principal Investigator |
SATO Shin Aomori University of Health and Welfare, 健康科学部, 教授 (40310099)
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| Co-Investigator(Kenkyū-buntansha) |
IZAWA Hiromi 青森県立保健大学, 健康科学部, 講師 (20315534)
MUKAI Yuuka 青森県立保健大学, 健康科学部, 助教 (60331211)
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| Co-Investigator(Renkei-kenkyūsha) |
KURASAKI Masaaki 北海道大学, 大学院・地球環境科学研究科, 助教 (80161727)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 胎児期低栄養 / 高血圧 / エネルギー代謝 / NAD(P)Hオキシダーゼ / AMP活性化プロテインキナーゼ / ポリフェノール / ラット |
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| Research Abstract |
In this study, maternal protein restriction during gestation and lactation elevated the blood pressure of rat offspring with aging. This was associated with the down-regulated endothelial nitric oxide synthase phosphorylation and the increased levels of mRNA of NAD(P)H oxidase subunits. When protein-restricted mothers during gestation were fed with polyphenol (PP) during lactation, the activity of AMP-activated protein kinase was up-regulated in adult offspring programmed by maternal protein restriction. Our results suggested that PP intake during lactation may affect energy metabolism.
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