2010 Fiscal Year Final Research Report
Establishment of system to elucidate mechanism for beneficial effect of collagen peptide by ingestion.
| Project/Area Number |
20500712
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyoto Prefectural University |
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Principal Investigator |
SATO Kenji Kyoto Prefectural University, 大学院・生命環境科学研究科, 教授 (00202094)
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| Co-Investigator(Kenkyū-buntansha) |
SHIGEMURA Yasutaka 京都府立大学 (20373178)
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| Project Period (FY) |
2008 – 2010
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| Keywords | コラーゲン / Pro-Hyp / 線維芽細胞 / ペプチド / 皮膚 |
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| Research Abstract |
A novel food-derived collagen peptide ; Hyp-Gly was identified in the human peripheral blood. Hyp-Gly stimulated growth of primary cultured fibroblast on collagen gel. The present study also demonstrated that fibroblast migrated from mouse skin expressed peptide transporter 1 and 2 (PEPT1, 2). However, expression of PEPT1, 2 dramatically decreased after several passages. These facts suggest that absorption of the collagen peptide through PEPT1, 2 might play significant role in cell proliferation by collagen peptide.
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[Journal Article] Identification of a novel food-derived collagen peptide, hydroxyprolyl-glycine, in human peripheral blood by pre-column derivatisation with phenyl isothiocyanate.2011
Author(s)
Shigemura, Y., Akaba, S., Kawashima, E., Park E.-Y. Nakamura, Y., Sato, K.
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Journal Title
Peer Reviewed
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[Journal Article] Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate.2010
Author(s)
Ichikawa, S., Morifuji, M., Ohara, H., Matsumoto, H., Takeuchi, Y., Sato, K.
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Journal Title
Int.J.Food Sci.Nutri. 61
Pages: 52-60
Peer Reviewed
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[Journal Article] Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin.2009
Author(s)
Shigemura, Y., Iwai, K., Morimatsu, F., Iwamoto, T., Mori, T., Oda, C. Taira, T., Park, E.Y., Nakamura, Y., Sato, K.
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Journal Title
J.Agric.Food Chem. 57(2)
Pages: 444-449
Peer Reviewed
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