2011 Fiscal Year Final Research Report
Estimation of animal experiment models to evaluate the early inflammation stage in adipocytes following obesity and investigation of anti-inflammatory factors in foods
| Project/Area Number |
20500720
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Otsuma Women's University |
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Principal Investigator |
AOE Seiichiro 大妻女子大学, 家政学部, 教授 (90365049)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 栄養学 / 肥満 / 脂肪細胞 / 炎症 / 動物実験 |
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| Research Abstract |
We investigated the influences of high fat or low fat diet and feeding periods on the mRNA expressions of adipocyte inflammatory parameters in C57BL/6J, KK/Ta, B6db/+(leptin receptor deficient hetero type) mice. Our results indicated that significant increase in abdominal fat mass and mRNA expressions of inflammatory parameters were observed after 4 weeks feeding of the high fat diet. On the short term feeding, detectable inflammatory parameters were NADPH oxidase subunits, MCP-1, IL-6, resistin. Impaired glucose tolerance and adipocyte enlargement were observed on the 8 or 12 weeks feeding. Using these parameters, anti-inflammatory effects of barley and dairy calcium were observed.
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