2010 Fiscal Year Final Research Report
Effect of excessive intake of trace elements caused by taking dietary supplements on senile neuropathy
| Project/Area Number |
20500729
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyoto Koka Women's University |
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Principal Investigator |
YOSHIDA Kaoru Kyoto Koka Women's University, 健康科学部, 教授 (10336787)
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| Co-Investigator(Kenkyū-buntansha) |
TERAMOTO Keiko 大阪市立大学, 大学院・医学研究科, 講師 (70047356)
GI Min 大阪市立大学, 大学院・医学研究科, 講師 (70336783)
KAWAZOE Sadahiro 京都府立大学, 生命環境科学研究科, 准教授 (00224783)
KITAMURA Mari 武庫川女子大学, 生活環境学部, 講師 (40369666)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 微量元素 / サプリメント / アルミニウム / マンガン / 神経障害 / 行動毒性 |
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| Research Abstract |
Some of botanical supplements analyzed contained high concentration of Aluminium (Al) and manganese (Mn). Al and Mn are known to have neurotoxic effects. We investigated the effect of chronic exposure to Al and/or Mn on animal behavior. Chronic exposure to Al or Mn inhibited wheel-running activity in mice. Chronic exposure to Al did not affect the passive avoidance performance, but Mn inhibited avoidance performance in dose-dependent manner in rats. We conducted a questionnaire survey to investigate the use of dietary supplements and dietary habits in adults. Supplement users had more healthy eating habits than the non-users. 66 % of the dietary supplement users took the supplements every day. The risk of excessive intake might be increased by trace elements in food plus that in dietary supplements.
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