2010 Fiscal Year Final Research Report
Fundamental study on safety estimation of functional foods with the guidance of aryl hydrocarbon receptor activation
| Project/Area Number |
20500733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Matsuyama University |
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Principal Investigator |
AMAKURA Yoshiaki Matsuyama University, 薬学部, 准教授 (50321857)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 健康と食生活 |
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| Research Abstract |
The aryl hydrocarbon receptor (AhR) mediates the toxic and biological actions of dioxins. We previously demonstrated that several natural aryl hydrocarbon receptor ligands from foods showed a dioxin-like activity at high concentration levels. In this study, to pursue the possible use as a probe for estimating the safety of functional foods, which predicts an excess intake of food constituents, the influence of health food materials on the AhR was evaluated. As a result, most tested samples did not show any AhR activation at high concentration levels, but some samples promoted the AhR activity in the range of high concentration levels at 10^6-10^9-fold compared to that of dioxin. Furthermore, several new natural AhR ligands were characterized from the AhR activated fractions of health food materials.
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