2010 Fiscal Year Final Research Report
Roles of odorant receptor signaling in axonal projection of olfactory sensory neurons
| Project/Area Number |
20509002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IMAI Takeshi The University of Tokyo, 大学院・理学系研究科, 客員共同研究員 (70509851)
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| Project Period (FY) |
2008 – 2010
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| Keywords | シグナル伝達 / 発生・再生 / 神経科学 / 脳・神経 |
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| Research Abstract |
In this study, we found that odorant receptors control axonal projection of olfactory sensory neurons via Gs and Golf, each controlling distinct phase of axon guidance. We also analyzed the pre-target axon sorting for olfactory map formation in mice, and found that pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons.
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