2010 Fiscal Year Final Research Report
Molecular mechanisms of the neuronal production and migration in the adult zebrafish brain
| Project/Area Number |
20509005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Nagoya City University |
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Principal Investigator |
KISHIMOTO Norihito Nagoya City University, 大学院・医学研究科, 研究員 (50508299)
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| Co-Investigator(Renkei-kenkyūsha) |
SAWAMOTO Kazunobu 名古屋市立大学, 大学院・医学研究科, 教授 (90282350)
KAWAKAMI Koichi 国立遺伝学研究所, 教授 (70195048)
NONAKA Shigenori 基礎生物学研究所, 准教授 (90435529)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 再生医学 / 神経科学 / 脳・神経 / 脳神経疾患 / 発生・分化 |
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| Research Abstract |
To provide new insights into the cellular and molecular mechanisms of adult neurogenesis and neuronal migration, we have studied neuronal production and migration in the adult zebrafish telencephalon. (1) Using systematic immunohistochemical and ultrastructural studies, we defined the cellular composition of the ventricular zone (VZ) in the adult zebrafish telencephalon. (2) We provided direct evidence that neuronal precursors migrate from the telencephalic VZ to the olfactory bulb in the adult zebrafish brain using a transgenic zebrafish line that expresses GFP in neuronal precursors. (3) We established a novel zebrafish model to study injury-induced neurogenesis in the adult brain.
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