2010 Fiscal Year Final Research Report
Study on the Mechanism of Apoptosis Induced by Ionizing Radiation in C3H Mouse Macrophages
| Project/Area Number |
20510058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
KUBOTA Yoshihisa National Institute of Radiological Sciences, 放射線防護研究センター, チームリーダー (70161685)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 放射線 / 感受性 / アポトーシス / マウス / マクロファージ |
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| Research Abstract |
It has been elucidated that radiation-induced apoptosis in C3H mouse macrophages is attributed to the decreased protein synthesis that subsequently resulted in the depletion of Mcl-1, an anti-apoptotic Bcl-2 protein. The present study revealed that radiation-induced suppression of global protein synthesis resulted from the sequential intracellular responses from DNA damages to eIF2alpha phosphorylation.
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