2010 Fiscal Year Final Research Report
The effect of environmental chemicals on the interaction of thyroid hormone receptor and retinoic acid receptor-related orphan receptor (ROR).
| Project/Area Number |
20510061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Gunma University |
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Principal Investigator |
IWASAKI Toshiharu Gunma University, 大学院・医学系研究科, 講師 (80375576)
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| Co-Investigator(Kenkyū-buntansha) |
KOIBUCHI Noriyuki 群馬大学, 大学院・医学系研究科, 教授 (80234681)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 小脳初代培養細胞 / Purkinje細胞 / 顆粒細胞 / 環境化学物質 / 甲状腺ホルモン / 脳発達抑制 / ROR |
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| Research Abstract |
(1) We investigated the effect of interaction between thyroid hormone receptor (TR) and retinoic acid receptor-related orphan receptor (ROR).
(2) We investigated the effects of Brominated Organic Chemicals (BOCs) such as polybrominated diphenylethers (PBDEs) on TR-related signaling using newly developed primary culture-based assays.
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[Journal Article] Activation of aromatase expression by retinoic acid receptor-related orphan receptor (ROR) alpha in breast cancer cells : identification of a novel ROR response element.2009
Author(s)
Odawara H, Iwasaki T, Horiguchi J, Rokutanda N, Hirooka K, Miyazaki W, Koibuchi Y, Shimokawa N, Iino Y, Takeyoshi I, Koibuchi N
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Journal Title
J Biol Chem. 284
Pages: 17711-17719
Peer Reviewed
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[Journal Article] Augmentation of estrogen receptor-mediated transcription by steroid and xenobiotic receptor.2008
Author(s)
Rokutanda N, Iwasaki T, Odawara H, Nagaoka R, Miyazaki W, Takeshita A, Koibuchi Y, Horiguchi J, Shimokawa N, Iino Y, Morishita Y, Koibuchi N
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Journal Title
Endocrine. 33
Pages: 305-316
Peer Reviewed
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