2010 Fiscal Year Final Research Report
Research for effect of cadmium induced-toxicity on FGF23 signaling
| Project/Area Number |
20510068
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Risk sciences of radiation/Chemicals
|
|---|
| Research Institution | Tokyo Women's Medical University |
|---|
Principal Investigator |
KUROSU Hiroshi Tokyo Women's Medical University, 大学院・医歯薬学総合研究科, 准教授 (40468690)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MATSUOKA Masato 東京女子医科大学, 医学部, 教授 (50209516)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | カドミウム |
|---|
| Research Abstract |
Cadmium is an important occupational and environmental pollutant. It has a biological half-life exceeding 20 years, and may accumulate in various organs such as kidney. The present results showed that cadmium exposure affected FGF23 induced-gene expression which was related with vitamin D metabolism.
|
-
-
[Journal Article] Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.2010
Author(s)
Goetz R, Nakada Y, Hu MC, Kurosu H, Wang L, Nakatani T, Shi M, Eliseenkova AV, Razzaque MS, Moe OW, Kuro-o M, Mohammadi M
-
Journal Title
Proc Natl Acad Sci USA 107
Pages: 407-412
-
-
-
-
-
-
-
-
-
-
-
-
-
-
