2010 Fiscal Year Final Research Report
Development of environmentally benign synthesis towards new biologically active substance
| Project/Area Number |
20510203
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
NISHIYAMA Shigeru Keio University, 理工学部, 教授 (20137988)
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| Co-Investigator(Kenkyū-buntansha) |
MAKI SHOJIRO 電気通信大学, 電気通信学部, 助教 (20266349)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 天然物有機化学 |
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| Research Abstract |
Anodic oxidation of halogenated phenols, which was an efficient synthetic protocol of diaryl ethers shared by isodityrosine natural products, enabled optimization of cyclization reaction towards eurypamide, synthesis of diarylheptanolides, and methylthalibrine. Electrochemically generated hypervalent iodine oxidant was utilized for a synthesis of quinolinone derivatives, some of which were intermediates of tetrahydropyrroloiminoquinone alkaloids. Oxidation of aminodiaryls with the same oxidant provided carbazoles. Generation of methoxy radicals by BDD electrode in methanol solution was assessed, and reaction mechanism by this radical was discussed in neolignan synthesis.
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[Journal Article] Synthesis and antitumor activity of combretastatin D-4.2008
Author(s)
K.Uno, T.Tanabe, T.Ogamino, R.Okada, M.Imoto, S.Nishiyama, K.Uno, T.Tanabe, T.Ogamino, R.Okada, M.Imoto, S.Nishiyama
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Journal Title
HETEROCYCLES 75(2)
Pages: 291-296
Peer Reviewed
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