2010 Fiscal Year Final Research Report
Chemical synethesis of marine cyclic peptides for elucidation of their stereostrutures and biological activities.
| Project/Area Number |
20510204
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
SUENAGA Kiyotake Keio University, 理工学部, 准教授 (60273215)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 環状ペプチド / 立体構造 / Palau'amide / aurilide / miuraenamide / プロヒビチン / アクチン / 生物活性 / 合成研究 |
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| Research Abstract |
To determine the absolute stereochemistry of palau'amide we synthesized four possible diasteremers of palau'amide with regard to C37 and C38. Among the NMR spectra of the four synthetic diastereomers, that of 1 was identical to that of natural palau'amide. This established the complete stereostructure. SAR study of aurilide was carried out, and target biomolecule of aurilide was determined to be prohibitin in the mitochondria. Synthetic studies on miuraenamide have been carried out. Miuraenamide induces actin polymerization and stabilizes actin filament. In addition, isolation, structure determination, and synthetic studies of related compounds have been carried out.
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Research Products
(28 results)
