The mechanistic study of the nano-size switch in bio-system by advanced synchrotron method.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20550068
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Inorganic chemistry
• Research Institution: Toho University
• Principal Investigator: OHGO Yoshiki Toho University, 医学部, 准教授 (40287496)
• Project Period (FY): 2008 – 2010
• Keywords: 生物無機化学

Research Abstract

The functional mechanisms of the model complexes of the naturally occurring hemeproteins are studied by synchrotron X-ray structure analysis, and other advanced analytical methods. Some of these complexes showed quite interesting switching behavior of the magnetism that respond to the external stimuli such as temperature, light, and physical pressure.

Research Products

• [Journal Article] Electronic Structure of Highly Ruffled Low-Spin Iron(III) Porphyrinates with Electron Withdrawing Heptafluoropropyl Groups at the meso Positions (2010)
  • Author(s): A. Tozuka, Y.Ohgo, A. Ikezaki, M. Taniguchi, M. Nakamura
  • Journal Title: Inorganic Chemistry 49 Pages: 10400-10408
  • Peer Reviewed
• [Journal Article] Regulation of heme electronic structure by means of axial ligand and core modification. (2009)
  • Author(s): M. Nakamura, Y.Ohgo, A. Ikezaki, S. Kouno
  • Journal Title: J.Biol.Inorg.Chem. 14(Suppl. 1) Pages: S128
  • Peer Reviewed
• [Journal Article] Isocyanide probe for the determination of the electronic structure in iron(III) porphyrinoids. (2009)
  • Author(s): Y.Ohgo, S. Neya, D. Hashizume, M. Nakamura
  • Journal Title: J.Biol.Inorg.Chem. 14(Suppl. 1) Pages: S229
  • Peer Reviewed
• [Journal Article] NMR studies on the electronic structure of one-electron oxidized complexes of iron(III) porphyrinates. (2009)
  • Author(s): A. Ikezaki, Y.Ohgo, M. Nakamura
  • Journal Title: Coordination Chemistry Revie ws 253(15-16) Pages: 2056-2069
  • Peer Reviewed
• [Journal Article] IUCr2008特集 -鉄(III)ポルフィリン類縁化合物におけるスピンクロスオーバートライアングル(MS31) (2009)
  • Author(s): 大胡惠樹,橋爪大輔,根矢三郎,中村幹夫
  • Journal Title: 日本結晶学会誌 51 Pages: 62-64
• [Journal Article] ヘム:生体内のナノサイズスイッチ (2008)
  • Author(s): 大胡惠樹
  • Journal Title: 東邦医学会雑誌 55 Pages: 223-226
  • Peer Reviewed
• [Journal Article] Electronic Structure of Six-Coordinate Iron(III) Monoazaporphyrins. (2008)
  • Author(s): K. Nakamura, A. Ikezaki, Y.Ohgo, T. Ikeue, S. Neya, M. Nakamura
  • Journal Title: Inorganic Chemistry 47 Pages: 10299-10307
  • Peer Reviewed
• [Journal Article] Factors that stabilize the (d_<xz>, d_<yz>)^3(d_<xy>)^1 (d_<z2>)^1 electron configuration in iron(III) por phyrinates : A case of bis(benzaldehyde) complex. (2008)
  • Author(s): A. Ikezaki, Y.Ohgo, T. Watanabe, M. Nakamu ra
  • Journal Title: Inorganic Chemistry Communi cations 11 Pages: 1198-1201
  • Peer Reviewed
• [Journal Article] Bis(1-methylimidazole) Complex of Iron(III) Oxypyriporphyrin Adopting an Intermediate-spin State. (2008)
  • Author(s): H. Eguchi, Y.Ohgo, A. Ikezaki, S. Neya, M. Nakamura
  • Journal Title: Chem Lett 37 Pages: 768-769
  • Peer Reviewed
• [Journal Article] Electronic ground state of low-spin iron(III) porphyrinoids. (2008)
  • Author(s): M. Nakamura, Y.Ohgo, A. Ikezaki
  • Journal Title: J Inorg Biochem 102(Review) Pages: 433-445
  • Peer Reviewed
• [Journal Article] Electronic properties in a five-coord inate azido complex of nonplanar iron(III) porphyrin : revisiting to quantum mechanical spin admixing. (2008)
  • Author(s): S. Neya, A. Takahashi, H. Ode, T. Hoshino, M. Hata, A. Ikezaki, Y.Ohgo, M. Takahashi, H. Hiramatsu, T. Kitagawa, Y. Furutani, V. A. Lorentz-Fonfria, H. Kandori, N. Funasaki, M. Nakamura
  • Journal Title: Bull Chem Soc Jpn 81 Pages: 136-141
  • Peer Reviewed
• [Presentation] 配位子場と外部刺激に基づくヘムの電子状態のチューニング (2011)
  • Author(s): 大胡惠樹
  • Organizer: 第12回メスバウアー分光研究会シンポジウム
  • Place of Presentation: 東京大学工学部,東京都(招待講演)
  • Year and Date: 2011-03-25
• [Presentation] 外部刺激応答型の新規機能性へム,感染症・免疫難病の先進医療開発 (2011)
  • Author(s): 大胡惠樹,橋爪大輔,高橋一志,森初果,速水真也,藤原基靖,根矢三郎,生天目由紀子,中村幹夫
  • Organizer: 平成22年度 事業報告会
  • Place of Presentation: 東邦大学,東京都
  • Year and Date: 2011-03-25
• [Presentation] Electro nic structure of highly ruffled low spin iron(III) porphyrinates with electron withdrawing heptafluoropropyl groups at the meso positions (2010)
  • Author(s): A. Tozuka, M. Taniguchi, S. Kouno, A. Ikezaki, Y.Ohgo, M. Nakamura
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2010-12-19
• [Presentation] Seeking the low-spin iron(III) porphyri noids with the purest (d_<xz>, d_<yz>)^4 (d_<xy>)^1 ground state. (2010)
  • Author(s): A. Ikezaki, J. Ono, Y.Ohgo, M. Nakamura
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2010-12-19
• [Presentation] Approaches toward the Heme Electronic Structure. (2010)
  • Author(s): Y.Ohgo, D. Hashizume, Y. Harada, M. Nakamura
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu, Hawaii, USA(Invited Lecture)
  • Year and Date: 2010-12-18
• [Presentation] ヘムモデルの異常な外部刺激応答性 (2010)
  • Author(s): 大胡惠樹
  • Organizer: 第4回東北大学G-COE研究会「金属錯体の固体物性科学最前線-錯体化学と固体物性物理と生物物性の連携新領域創成を目指して-」
  • Place of Presentation: 東北大学理学部,宮城県
  • Year and Date: 2010-12-04
• [Presentation] ヘム錯体の外部刺激応答性 (2010)
  • Author(s): 大胡惠樹,橋爪大輔,高橋一志,森初果,速水真也,根矢三郎,中村幹夫
  • Organizer: 平成22年度日本結晶学会年会
  • Place of Presentation: 大阪大学コンベンションセンター,大阪府
  • Year and Date: 2010-12-03
• [Presentation] Electronic structure of highly ruffled low-spin iron (III) porphyrinates with electron withdrawing heptafluoro propyl groups at the meso positions. (2010)
  • Author(s): A. Tozuka, A. Ikezaki, Y.Ohgo, M. Nakamura
  • Organizer: The 4th High-Tech Research Center Sympo sium
  • Place of Presentation: Toho University, Chiba, Japan
  • Year and Date: 2010-11-27
• [Presentation] Electronic structure of highly ruffled low-spin iron(III) porphy rinates with electron withdrawing hepta fluoropropyl groups at the meso positions (2010)
  • Author(s): A. Tozuka, Y.Ohgo, A. Ikezaki, M. Tanigu chi, M. Nakamura
  • Organizer: 7th Joint Academic Meeting of the three Faculties of Toho University
  • Place of Presentation: Toho University, Chiba, Japan
  • Year and Date: 2010-10-09
• [Presentation] Heme Electronic Structure as Studied by NMR, EPR, and Mossbauer Spectroscopy (2010)
  • Author(s): M. Nakamura, Y.Ohgo, A. Ikezaki, M. Takahashi
  • Organizer: 7th Joint Academic Meeting of the three Faculties of Toho University
  • Place of Presentation: Toho University, Chiba, Japan
  • Year and Date: 2010-10-09
• [Presentation] Spin-spin interactions in iron(III) porphyrin radical cations with ruffled and saddled structure (2010)
  • Author(s): S. Kouno, A. Ikezaki, Y.Ohgo, M. Nakamura
  • Organizer: 7th Joint Academic Meeting of the three Faculties of Toho University
  • Place of Presentation: Toho University, Chiba, Japan
  • Year and Date: 2010-10-09
• [Presentation] Exploration and Utilization of Heme Electronic Structure (2010)
  • Author(s): Y.Ohgo, D. Hashizume, K. Takahashi, H. Mori, S. Hayami, S. Neya, M. Nakmura
  • Organizer: 60th Conference on Coordination Chemistry
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2010-09-27
• [Presentation] メソ位に嵩高い電子吸引基を持つラッフル変形した低スピン-鉄(III)ポルフィリン錯体の電子構造 (2010)
  • Author(s): 戸塚瑛,谷口美代子,大胡惠樹,池崎章,中村幹夫
  • Organizer: 第60回錯体化学討論会
  • Place of Presentation: 大阪国際交流センター,大阪府
  • Year and Date: 2010-09-27
• [Presentation] ポルフィリン鉄(III)ラジカルカチオンにおける軌道間相互作用 (2010)
  • Author(s): 河野壮平,大胡惠樹,池崎章,中村幹夫
  • Organizer: 第60回錯体化学討論会
  • Place of Presentation: 大阪国際交流センター,大阪府
  • Year and Date: 2010-09-27
• [Presentation] ヘムの電子状態と外部刺激応答性 (2010)
  • Author(s): 大胡惠樹
  • Organizer: 第一回 碧き山の会"新しい分子科学と放射光I"
  • Place of Presentation: 青山学院大学相模原キャンパス,神奈川県(招待講演)
  • Year and Date: 2010-09-04
• [Presentation] Observation of an Extremely Labile Spin State in Mono(Imidazole) and Related Complexes of Iron(III) Porphyri nates (2010)
  • Author(s): M. Nakamura, A. Ikezaki, Y.Ohgo, M. Takahashi
  • Organizer: 6th International Conference on Porphyrins and Phthalocyanines
  • Place of Presentation: Santa Ana Pueblo, USA(Keynote Lecture)
  • Year and Date: 2010-07-08
• [Presentation] Synthesis and Electronic Structure of Low-Spin Iron(III) meso-Tetraalkylchlorin Complexes (2010)
  • Author(s): A. Ikezaki, J. Ono, Y.Ohgo, M. Nakamura
  • Organizer: 6th International Conference on Porphyrins and Phthalocyanines
  • Place of Presentation: Santa Ana Pueblo, USA
  • Year and Date: 2010-07-08
• [Presentation] Response of the d_π-p_π Interaction to the Environmental Stimuli in Iron(III) Heme (2010)
  • Author(s): Y.Ohgo, D. Hashizume, K. Takahashi, H. Mori, S. Hayami, S. Neya, M. Nakamura
  • Organizer: 6th International Conference on Porphyrins and Phthalocyanines
  • Place of Presentation: Santa Ana Pueblo, USA
  • Year and Date: 2010-07-07
• [Presentation] 生体ヘムを模倣した外部刺激応答型機能性物質の創成 (2010)
  • Author(s): 大胡惠樹
  • Organizer: 第22回超分子創製セミナー
  • Place of Presentation: 立命館大学総合理工学院薬学部薬学科,滋賀県(招待講演)
  • Year and Date: 2010-06-18
• [Presentation] ポルフィリン類縁体モデルを用いたヘムの電子状態の解明 (2010)
  • Author(s): 大胡惠樹
  • Organizer: 第4回生物物質科学フォーラム
  • Place of Presentation: 北陸先端大東京サテライトキャンパス,東京都(招待講演)
  • Year and Date: 2010-05-26
• [Presentation] ヘムの電子状態の探索,模倣と応用 (2010)
  • Author(s): 大胡惠樹
  • Organizer: 第11回生体分子科学コロキウム
  • Place of Presentation: いばらき量子ビーム研究センター,茨城県(招待講演)
  • Year and Date: 2010-05-12
• [Presentation] 環境刺激に応答するへムの機能 (2010)
  • Author(s): 大胡惠樹
  • Organizer: 第2回「感染症・免疫難病の先進医療技術開発」事業報告会
  • Place of Presentation: 東邦大学,東京都
  • Year and Date: 2010-03-25
• [Presentation] Spin crossover in saddle shaped ferric porphyrinates. (2010)
  • Author(s): M. Nakamura, Y.Ohgo, A. Ikezaki, M. Takahashi
  • Organizer: 239th American Chemical Society National Meeting
  • Place of Presentation: San Francisco, USA(Invited Lecture)
  • Year and Date: 2010-03-23
• [Presentation] ヘムの分子構造,電子構造のデザイン及び,空間制御による新規環境刺激応答型機能性物質の創成 (2010)
  • Author(s): 大胡惠樹
  • Organizer: 分子研研究会:分子集合系におけるポテンシャル空間の制御～その錯体化学的アプローチ～
  • Place of Presentation: 分子科学研究所,愛知県(招待講演)
  • Year and Date: 2010-02-20
• [Presentation] 環境刺激応答によるヘムの電子状態制御 (2009)
  • Author(s): 大胡惠樹
  • Organizer: 第3回東北大学G-COE研究会「金属錯体の固体物性科学最前線-錯体化学と固体物性物理と生物物性の連携新領域創成を目指して-」
  • Place of Presentation: 東北大学理学部,宮城県(招待講演)
  • Year and Date: 2009-12-19
• [Presentation] Biomimetic approach to the development of switching materials with iron(III) porphyrinoids. (2009)
  • Author(s): Y.Ohgo, S. Neya, D. Hashizume, M. Nakamura
  • Organizer: International Symposium on "Multifunctional Organic Materials and Devices"
  • Place of Presentation: Funabashi, Chiba
  • Year and Date: 2009-12-12
• [Presentation] Switchable spin states in deformed iron(III) porphyrin complexes. (2009)
  • Author(s): M. Nakamura, Y.Ohgo, A. Ikezaki, M. Takahashi
  • Organizer: International Symposium on Multi functional Organic Materials and Devices
  • Place of Presentation: Funabashi, Japan
  • Year and Date: 2009-12-12
• [Presentation] 生体ヘムタンパク質のメカニズムを利用した環境応答型機能性物質の開発 (2009)
  • Author(s): 大胡惠樹
  • Place of Presentation: 熊本大学大学院自然科学研究科セミナー,熊本大学理学部,熊本県(招待講演)
  • Year and Date: 2009-11-16
• [Presentation] Electron configuration cross over behavior in iron(III) porphyrinoids. (2009)
  • Author(s): Y.Ohgo, S. Neya, D. Hashizume, M. Nakamura
  • Organizer: 2nd ACCC
  • Place of Presentation: Nanjing, China
  • Year and Date: 2009-11-03
• [Presentation] Regulation of heme electronic structure by means of axial ligands and porphyrin deformation. (2009)
  • Author(s): M. Nakamura, Y.Ohgo, A. Ikezaki, M. Takahashi
  • Organizer: 10th International Symposium on Applied Bioinorganic Chemistry
  • Place of Presentation: Debrecen, Hungary(Invited Lecture)
  • Year and Date: 2009-09-27
• [Presentation] ポルフィリン類縁鉄(III)錯体の電子配置の温度依存性 (2009)
  • Author(s): 大胡惠樹,根矢三郎,高橋正,橋爪大輔,中村幹夫
  • Organizer: 第59回錯体化学討論会
  • Place of Presentation: 長崎大学,長崎県
  • Year and Date: 2009-09-27
• [Presentation] 異常な電子状態を有する大きなラッフル変形ポルフィリン鉄錯体 (2009)
  • Author(s): 池崎章,大胡惠樹,中村幹夫
  • Organizer: 第59回錯体化学討論会
  • Place of Presentation: 長崎大学,長崎県
  • Year and Date: 2009-09-26
• [Presentation] 非平面ポルフィリン鉄(III)錯体の1電子酸化生成物におけるスピン-スピン相互作用 (2009)
  • Author(s): 河野壮平,池崎章,大胡惠樹,中村幹夫
  • Organizer: 第59回錯体化学討論会
  • Place of Presentation: 長崎大学,長崎
  • Year and Date: 2009-09-25
• [Presentation] External Stimulation Response of the Heme Electronic Structure (2009)
  • Author(s): Y.Ohgo, S. Neya, D. Hashizume, M. Nakamura
  • Organizer: 7th China Japan Cross Science Symposium
  • Place of Presentation: Fuzhou, Jiangxi, China(Invited Lecture)
  • Year and Date: 2009-09-24
• [Presentation] Unusual Switching Behavior Among Electron Configurations in Iron(III) Porphyrinoids. (2009)
  • Author(s): Y.Ohgo, S. Neya, D. Hashizume, M. Nakamura
  • Organizer: 42nd IUPAC
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2009-08-03
• [Presentation] Isocyanide Probe for the Determination of the Electronic Structure in Iron(III) Porphyrinoids. (2009)
  • Author(s): Y.Ohgo, S. Neya, D. Hashizume, M. Nakamura
  • Organizer: ICBIC14
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2009-07-27
• [Presentation] Regulation of heme electronic structure by means of axial ligand and core modification (2009)
  • Author(s): M.Nakamura, A. Ikezaki, Y.Ohgo, S. Kouno
  • Organizer: ICBIC14
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2009-07-26
• [Presentation] Electronic Structure of One Electron Oxidized Products of Iron(III) Por phyrinates. (2009)
  • Author(s): M. Nakamura, A. Ikezaki, Y.Ohgo, S. Kouno
  • Organizer: 2nd Georgian Bay Inter national Conference on Bioinorganic Chemistry
  • Place of Presentation: Parry Sound, Ontario, Canada (Invited Lecture)
  • Year and Date: 2009-05-28
• [Presentation] 先進構造解析手法を用いたヘムの電子状態解明と機能性材料化に対するアプローチ (2009)
  • Author(s): 大胡惠樹
  • Organizer: 慶応義塾大学理工学部セミナー
  • Place of Presentation: 慶応義塾大学日吉キャンパス,神奈川県(招待講演)
  • Year and Date: 2009-05-10
• [Presentation] 放射光を用いたヘムタンパク質モデルの構造解析手法の開発 (2009)
  • Author(s): 大胡惠樹
  • Organizer: 第1回感染症・免疫難病の先進医療技術開発」事業報告会
  • Place of Presentation: 東邦大学,東京都
  • Year and Date: 2009-03-25
• [Presentation] The importance of the NMR chemical shift and frontier orbital theory in the determination of electronic structure of heme. (2009)
  • Author(s): セミナー, S. Neya, D. Hashizume, A. Hoshino, K. Nakamura, S. Kouno, M. Nakamura
  • Organizer: Symposium of Quantum Biological Molecular Science
  • Place of Presentation: Mito(Invited Lecture)
  • Year and Date: 2009-02-20
• [Presentation] 磁性評価における放射光粉末構造解析の必要性 (2009)
  • Author(s): 大胡惠樹
  • Organizer: 第6回有機・粉末結晶構造解析研究会
  • Place of Presentation: 東邦大学,東京都(招待講演)
  • Year and Date: 2009-01-30
• [Presentation] ヘムタンパク質の機能発現のメカニズムと電子状態の解明 (2008)
  • Author(s): 大胡惠樹
  • Organizer: 第2回東邦大学3学部合同学術集会
  • Place of Presentation: 東邦大学,東京都
  • Year and Date: 2008-11-29
• [Presentation] The Electron Configuration Crossover Behavior Observed in a Single Molecule. (2008)
  • Author(s): Y.Ohgo, S. Neya, D. Hashizume, M. Nakamura
  • Organizer: CJCSS-6
  • Place of Presentation: Zhengzhou, China(Invited Lecture)
  • Year and Date: 2008-10-24
• [Presentation] ヘムモデル鉄(III)錯体のスピンクロスオーバートライアングルと電子配置変換挙動 (2008)
  • Author(s): 大胡惠樹
  • Organizer: 第2回東邦大学複合物性研究センターシンポジウム 新規多機能有機材料の創成と評価(文部科学省ハイテク・リサーチ・センター整備事業)
  • Place of Presentation: 東邦大学,千葉県
  • Year and Date: 2008-10-10
• [Presentation] サドル型ポルフィリン鉄錯体における鉄-ポルフィリン軌道間相互作用 (2008)
  • Author(s): 河野壮平,星野哲人,池崎章,大胡惠樹,中村幹夫
  • Organizer: 第58回錯体化学討論会
  • Place of Presentation: 金沢大学,石川県
  • Year and Date: 2008-09-20
• [Presentation] ポルフィリン類縁体鉄(III)錯体のスピンクロスオーバー及び電子配置変換挙動 (2008)
  • Author(s): 大胡惠樹,江口創,中村賢一郎,池崎章,根矢三郎,高橋正,橋爪大輔,中村幹夫
  • Organizer: 第58回錯体化学討論会
  • Place of Presentation: 金沢大学,石川県
  • Year and Date: 2008-09-20
• [Presentation] The Spin-crossover Triangle in the Iron(III) Porphyrinoids (2008)
  • Author(s): Y.Ohgo, S. Neya, D. Hashizume, M. Nakamura
  • Organizer: 3rd Inter national Minisymposium on Coordination Chemistry for Advanced Materials
  • Place of Presentation: Kana gawa(Invited Lecture)
  • Year and Date: 2008-09-18
• [Presentation] The Spin-crossover Triangle in the Iron(III) Porphyrinoids (2008)
  • Author(s): Y.Ohgo, S. Neya, D. Hashizume, M. Nakamura
  • Organizer: IUCr2008 XXI Congress and General Assembly of the International Union of Crystallography
  • Place of Presentation: Osaka(Invited Lecture).
  • Year and Date: 2008-08-26
• [Presentation] Unusual electronic structure in iron(III) porphyrinates and their oxidized product. (2008)
  • Author(s): M. Nakamura, Y.Ohgo, A. Ikezaki
  • Organizer: 38^<th> International Conference on Coordi nation Chemistry
  • Place of Presentation: Jerusalem, Israel(Invited lecture)
  • Year and Date: 2008-07-23
• [Presentation] The Spin-crossover Processes Observed in the 6-Coordinated Iron(III) Porphyrinoid Complexes. (2008)
  • Author(s): Y.Ohgo, S. Neya, D. Hashizume, M. Nakamura
  • Organizer: ICPP5
  • Place of Presentation: Moscow, Russia
  • Year and Date: 2008-07-10
• [Book] Electronic and Magnetic Structures of Iron Porphyrin Complexes, Handbook of the Porphyrin Science(Kadish K. M.; Smith K. M.; Guilard R., Eds.)(Vol. 7, Chapter 1, 1-146) (2010)
  • Author(s): M. Nakamura, Y. Ohgo, A. Ikezaki
  • Publisher: World Scientific Publishing Co Inc, Singapore