2010 Fiscal Year Final Research Report
Metal-catalyzed cross-coupling reaction between aryl and fluorofunctional groups by using strong electron-poor ligand
| Project/Area Number |
20550099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Okayama University |
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Principal Investigator |
KORENAGA Toshinobu Okayama University, 大学院・自然科学研究科, 助教 (70335579)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 芳香族フッ素化合物 / クロスカップリング / 還元的脱離反応 / 電子不足配位子 / 電子的効果 / DFT計算 |
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| Research Abstract |
Metal-catalyzed coupling reaction between aryl and fluorofunctional group was studied. Firstly, we investigated the electronic effect of supporting ligand on reductive elimination of biaryl. As a result, we found that the strong electron-poor diphosphine ligand accelerated reductive elimination of biaryl. Secondly, we tried the reductive elimination of aryl and fluorofunctional group from palladium catalyst bearing strong electron-poor ligand. However, the complex was decomposed before reductive elimination at high reaction temperature.
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