2010 Fiscal Year Final Research Report
Catalytic Generation of Chiral Silicon Enolates : Development of Direct Asymmetric Catalytic Reaction
| Project/Area Number |
20550101
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka City University |
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Principal Investigator |
HATANAKA Yasuo 大阪市立大学, 大学院・工学研究科, 教授 (80344117)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 触媒反応 / 反応 |
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| Research Abstract |
Mannich reaction between tosylimines and ketones smoothly took place in the presence of chiral silicon enolates, which were catalytically generated from the reaction of chiral Lewis acids with ketones, giving the corresponding Mannich adducts with moderate enantiomeric excess. In the presence of silicon Lewis acid catalysis,β,γ-unsaturatedγ-ractams react with tosylimines to afford 4, 5-disubstitutedγ-lactam in moderate yields. The most striking characteristic of this reaction is high atom economy.
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