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2010 Fiscal Year Final Research Report

Preparation of hydrophilic reactive biocompatible surface of amphiphilic block copolymer

Research Project

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Project/Area Number 20550108
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Polymer chemistry
Research InstitutionTokyo Institute of Technology

Principal Investigator

ISHIZONE Takashi  Tokyo Institute of Technology, 大学院・理工学研究科, 准教授 (60212883)

Co-Investigator(Renkei-kenkyūsha) YOKOYAMA Hideaki  東京大学, 新領域創成科学研究科, 准教授 (80358316)
Project Period (FY) 2008 – 2010
Keywords高分子合成
Research Abstract

A series of new amphiphilic block copolymers composed of water-soluble polymethacrylate and hydrophobic polystyrene was synthesized by the living anionic polymerization. Novel polymer surface showing hydrophilicity, reactivity, and biocompatibility was obtained by casting the block copolymer solution. The hydrophobic alkyl terminal groups in the side chains of polymethacrylate played important roles to achieve the surface segregation of water-soluble polymethacrylate segments.

  • Research Products

    (26 results)

All 2011 2010 2009 2008

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (5 results) Book (2 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Synthesis of Water-Soluble Poly[oligo(ethylene glycol) methacrylatels by Living Anionic Polymerization of Oligo(ethylene glycol) Vinyl Ether Methacrylates2011

    • Author(s)
      J.Yamanaka, T.Kayasuga, M.Ito, H.Yokoyama, T.Ishizone
    • Journal Title

      Polym.Chem. in press

    • Peer Reviewed
  • [Journal Article] Precise synthesis of thermo-responsive and water-soluble star-branched polymers and star bloc copolymers by living anionic polymerization.2011

    • Author(s)
      A.Hirao, R.Inushima, T.Nakayama, T.Watanabe, H.-S.Yoo, T.Ishizone, K.Sugiyama, T.Kakuchi, S.Carlotti, A.
    • Journal Title

      Deffieux Eur.Polym.J. 47

      Pages: 713-722

    • Peer Reviewed
  • [Journal Article] Crystal orientation of Poly(E-caprolactone) Homopolymers Confined in Cylindrical Nanodomains2010

    • Author(s)
      S.Nojima, Y.Oguma, K.Kadena, T.Ishizone, Y.Iwasaki, K.Yamaguchi
    • Journal Title

      Macromolecules 43

      Pages: 3916-3923

    • Peer Reviewed
  • [Journal Article] Living Anionic Polymerization of N-Methacryloylazetidine : Anionic Polymerizability of N, N-Dialkylmethacrylamides2010

    • Author(s)
      T.Suzuki, J.Kusakabe, K.Kitazawa, T.Nakagawa, S.Kawauchi, T.Ishizone
    • Journal Title

      Macromolecules 43

      Pages: 107-116

    • Peer Reviewed
  • [Journal Article] Synthesis of Well-Defined Poly(ethylene-alt-1-vinyladamantane) via Living Anionic Polymerization of 2-(1-Adamantyl)-1, 3-butadiene, Followed by Hydrogenation2009

    • Author(s)
      S.Kobayashi, H.Kataoka, T.Ishizone
    • Journal Title

      Macromolecules 42

      Pages: 5017-5026

    • Peer Reviewed
  • [Journal Article] Two Dimentional Nano-dot Array Engineering of Block Copolymer Surface Micelles on Water Surface2009

    • Author(s)
      S.Nagano, Y.Matsushita, S.Shinma, T.Ishizone, T.Seki
    • Journal Title

      Thin Solid Films 518

      Pages: 724-728

    • Peer Reviewed
  • [Journal Article] Living Anionic Polymerization of Styrenes Containing Adamantyl Skeletons2009

    • Author(s)
      S.Kobayashi, H.Kataoka, T.Ishizone
    • Journal Title

      Journal of Physics : Conference Series 184

      Pages: 012017

    • Peer Reviewed
  • [Journal Article] Synthesis of Well-defined Random and Block Copolymers of 2-(1-Adamantyl)-1,3-butadiene with Isoprene via Anionic Polymerization2009

    • Author(s)
      S.Kobayashi, H.Kataoka, T.Ishizone, T.Kato, T.Ono, S.Kubotaka, K.Arimoto, H.Ogi
    • Journal Title

      Reactive and Functional Polymers 69

      Pages: 409-415

    • Peer Reviewed
  • [Journal Article] Living Anionic Polymerization of 11-Methacryloy1-2-methylaziridine2009

    • Author(s)
      T.Ishizone, J.Kusakabe, T.Suzuki
    • Journal Title

      Macromolecular Symposia 279

      Pages: 21-28

    • Peer Reviewed
  • [Journal Article] アダマンタン骨格を有する高分子の精密合成2009

    • Author(s)
      石曽根隆
    • Journal Title

      有機合成化学協会誌 67

      Pages: 156-165

    • Peer Reviewed
  • [Journal Article] Synthesis and Properties of New Thermoplastic Elastomers Containing Poly[4-(1-adamantyl)styrene] Hard Segments2008

    • Author(s)
      S.Kobayashi, H.Kataoka, T.Ishizone, T.Kato, T.Ono, S.Kobutaka, H.Ogi
    • Journal Title

      Macromolecules 41

      Pages: 5502-5508

    • Peer Reviewed
  • [Journal Article] Reduced Hydrophobic Interaction of Polystyrene Surfaces by Spontaneous Segregation of Block Copolymers with Oligo(Ethylene Glycol) Methyl Ether Methacrylate Blocks : Force Measurements in Water Using Atomic Force Microscope with Hydrophobic Probes2008

    • Author(s)
      T.Ishizone, A.Seki, A.Oyane, H.Yokoyama
    • Journal Title

      Langmuir 24

      Pages: 5527-5533

    • Peer Reviewed
  • [Journal Article] Anionic Polymerizations of Oligo(ethylene glycol) Alkyl Ether Methacrylates : Effect of Side Chain Length and ω-Alkyl Group of Side Chain on Cloud Point in Water2008

    • Author(s)
      T.Ishizone, A.Seki, M.Hagiwara, S.Han, H.Yokoyama, A.Oyane, A.Deffieux, S.Carlotti
    • Journal Title

      Macromolecules 41

      Pages: 2963-2967

    • Peer Reviewed
  • [Journal Article] Living Anionic Polymerization of A-Methacryloyl-2-methylaziridine : Polymerizable N, N-Dialkylmethacrylamide2008

    • Author(s)
      T.Ishizone, T.Suzuki, J.Kusakabe
    • Journal Title

      Macromolecules 41

      Pages: 1929-1936

    • Peer Reviewed
  • [Journal Article] Crystallization of Homopolymers Confined in Spherical or Cylindrical Nanodomains2008

    • Author(s)
      S.Nojima, Y.Ohguma, S.Namiki, T.Ishizone, K.Yamaguchi
    • Journal Title

      Macromolecules 41

      Pages: 1915-1918

    • Peer Reviewed
  • [Presentation] Synthesis of novel polymers containing adamantyl skeletons2010

    • Author(s)
      T.Ishizone
    • Organizer
      PACIFICHEM2010
    • Place of Presentation
      国際会議場ホノルル,米国ハワイ州
    • Year and Date
      2010-12-18
  • [Presentation] Synthesis of Polymers Containing Adamantyl Skeletons2010

    • Author(s)
      T.Ishizone
    • Organizer
      2010 International Symposium on Nano Structures
    • Place of Presentation
      POSCO International Center (Pohang, Korea).
    • Year and Date
      2010-11-05
  • [Presentation] Living Anionic Polymerization of Styrenes Containing Adamantyl Skeletons2010

    • Author(s)
      T.Ishizone
    • Organizer
      ISAOP-10
    • Place of Presentation
      東京工業大学蔵前ホール、東京
    • Year and Date
      2010-09-28
  • [Presentation] Anionic Polymerizability of N-NDialkylmethacrylamides2010

    • Author(s)
      T.Ishizone
    • Organizer
      MACRO2010
    • Place of Presentation
      SECC, (Glasgow, UK)
    • Year and Date
      2010-07-13
  • [Presentation] Anionic polymerization of N,N-Dialkylmethacrylamides2010

    • Author(s)
      T.Ishizone
    • Organizer
      2010 JAPAN-TAIWAN BILATERAL POLYMER SYMPOSIUM
    • Place of Presentation
      北海道大学100周年記念館、札幌
    • Year and Date
      2010-07-01
  • [Book] Complex Macromolecular Architectures : Synthesis, Characterization, and Self-Assembly N.(Synthesis of Well-Defined Poly (meth)acrylamides with Varied Stereoregularity by Living Anionic Polymerization)(Hadjichristidis (Ed.))2011

    • Author(s)
      石曽根隆
    • Total Pages
      431-460.
    • Publisher
      Wiley, Asia
  • [Book] ベーシックマスター高分子化学(第10章アニオン重合)(西久保忠臣編)2011

    • Author(s)
      石曽根隆(分担)
    • Publisher
      オーム社
  • [Patent(Industrial Property Rights)] 1-メチレンインダン重合体及びその製造方法、ブロック共重合体及びその製造方法、並びに、光学フィルム2010

    • Inventor(s)
      石曽根隆、高嶋務、椎橋彬
    • Industrial Property Rights Holder
      東京工業大学、新日本石油株式会社
    • Industrial Property Number
      特願2010-032777
    • Filing Date
      2010-02-17
  • [Patent(Industrial Property Rights)] 1-メチレンテトラリン重合体及びその製造方法2010

    • Inventor(s)
      石曽根隆、高嶋務、椎橋彬
    • Industrial Property Rights Holder
      東京工業大学、新日本石油株式会社
    • Industrial Property Number
      特願2010-032781
    • Filing Date
      2010-02-17
  • [Patent(Industrial Property Rights)] 抗血栓性高分子組成物2010

    • Inventor(s)
      横山英明、大矢根綾子、石曽根隆、酒井克子
    • Industrial Property Rights Holder
      産業技術総合研究所
    • Industrial Property Number
      特許第4604177号
    • Acquisition Date
      2010-10-15
  • [Patent(Industrial Property Rights)] N-メタクリロイルアジリジン系重合体ならびにその重合体の製造方法2010

    • Inventor(s)
      石曽根隆、小林真盛
    • Industrial Property Rights Holder
      東京工業大学、リンテソク株式会社
    • Industrial Property Number
      特許第4588526号
    • Acquisition Date
      2010-09-17

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Published: 2012-01-26   Modified: 2016-04-21  

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