2010 Fiscal Year Final Research Report
Chemo-enzymatic synthesis of sulfated polysaccharides with well-defined structure
| Project/Area Number |
20550110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
OHMAE Masashi Kyoto University, 大学院・工学研究科, 助教 (50300801)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 酵素反応 / 高分子合成 / 生体材料 / 糖鎖 |
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| Research Abstract |
Glycosaminoglycans are sulfated polysaccharides having important biological activities, which regulate cellular differentiation and development. In the present study, precision synthesis of heparan sulfate and sulfated-Lewis X oligomers were challenged, which have quite complex structures and are difficult to be prepared chemically. The fluoride monomer for heparan sulfate synthesis was successfully prepared, and sulfated Lewis X-related oligosaccharides were obtained successfully. Further, potent inhibitors for heparanase were also synthesized successfully.
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