2010 Fiscal Year Final Research Report
Development of chaperone-peptide beads for control of toxic nano-particle
| Project/Area Number |
20550111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
TANAKA Naoki Kyoto Institute of Technology, 工芸科学研究科, 准教授 (60243127)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 環境分析 / 自己組織化 / 生体材料 / 脳・神経 / ナノ毒性 |
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| Research Abstract |
To develop chaperone-bead for detecting toxic nano-particle, the property of the chaperone peptide derived from the substrate binding site of the molecular chaperone αA-crystallin was studied. Chaperone peptide which corresponds to the residues 71-75 of αA-crystallin self-assemble into nano-scale fibril to efficiently reduce the aggregation of the substrate model protein. The substrate recognition mechanism of a the chaperon-peptide was studied.
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